acetic acid 0.166667 h; Heating;

1: 1.) sodium methoxide / 1.) MeOH, 0 deg C, 30 min; 2.) MeOH, reflux, 20 h 2: 99 percent / 85percent m-chloroperbenzoic acid / CH2Cl2 / 2 h 3: 72 percent / methylsulfonyl chloride, pyridine / 1.) 0 deg C, 2.) H2O, 40 deg C, 2 h 4: 98 percent / tetrahydrofuran / 5 h / Ambient temperature 5: 26 percent / 6percent sodium amalgam, disodium hydrogen phosphate / methanol / 5 h 6: 95 percent / 80percent aq. acetic acid / 0.17 h / Heating View Scheme

1: 99 percent / 85percent m-chloroperbenzoic acid / CH2Cl2 / 2 h 2: 72 percent / methylsulfonyl chloride, pyridine / 1.) 0 deg C, 2.) H2O, 40 deg C, 2 h 3: 98 percent / tetrahydrofuran / 5 h / Ambient temperature 4: 26 percent / 6percent sodium amalgam, disodium hydrogen phosphate / methanol / 5 h 5: 95 percent / 80percent aq. acetic acid / 0.17 h / Heating View Scheme

1: 98 percent / tetrahydrofuran / 5 h / Ambient temperature 2: 26 percent / 6percent sodium amalgam, disodium hydrogen phosphate / methanol / 5 h 3: 95 percent / 80percent aq. acetic acid / 0.17 h / Heating View Scheme

1: 72 percent / methylsulfonyl chloride, pyridine / 1.) 0 deg C, 2.) H2O, 40 deg C, 2 h 2: 98 percent / tetrahydrofuran / 5 h / Ambient temperature 3: 26 percent / 6percent sodium amalgam, disodium hydrogen phosphate / methanol / 5 h 4: 95 percent / 80percent aq. acetic acid / 0.17 h / Heating View Scheme

1: 80 percent / alkaline 2: 1.) sodium methoxide / 1.) MeOH, 0 deg C, 30 min; 2.) MeOH, reflux, 20 h 3: 99 percent / 85percent m-chloroperbenzoic acid / CH2Cl2 / 2 h 4: 72 percent / methylsulfonyl chloride, pyridine / 1.) 0 deg C, 2.) H2O, 40 deg C, 2 h 5: 98 percent / tetrahydrofuran / 5 h / Ambient temperature 6: 26 percent / 6percent sodium amalgam, disodium hydrogen phosphate / methanol / 5 h 7: 95 percent / 80percent aq. acetic acid / 0.17 h / Heating View Scheme

1: 26 percent / 6percent sodium amalgam, disodium hydrogen phosphate / methanol / 5 h 2: 95 percent / 80percent aq. acetic acid / 0.17 h / Heating View Scheme