(R)-1-(Boc-氨基)-2-丙醇合成路线 （共 6 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C; 2 h;
参考文献
Tucci, Fabio C.; Zhu, Yun-Fei; Guo, Zhiqiang; Gross, Timothy D.; Connors Jr., Patrick J.; Struthers, R. Scott; Reinhart, Greg J.; Saunders, John; Chen, Chen
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 19 p. 3317 - 3322
反应条件
sodium in tetrahydrofuran; ammonia T=-78°C; 0.25 h; Yields of byproduct given;
参考文献
Enders, Dieter; Haertwig, Andreas; Raabe, Gerhard; Runsink, Jan
European Journal of Organic Chemistry, 1998 , # 9 p. 1771 - 1792
反应条件
ammonia; sodium in tetrahydrofuran T=-78°C; 0.25 h;
参考文献
Enders, Dieter; Haertwig, Andreas; Rabe, Gerhard; Runsink, Jan
Angewandte Chemie, 1996 , vol. 108, # 20 p. 2540 - 2542
反应条件
in dichloromethane T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
WO2013/192350 A1, ;
Paragraph 00589 ;
反应条件
1: NEt3 / methanol; tetrahydrofuran / Ambient temperature 2: 75 percent / Na / tetrahydrofuran; liquid ammonia / 0.25 h / -78 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 9 p. 1771 - 1792
反应条件
1: 1.)isobutyl chloroformate, N-methylmorpholine; 2.)triethylamine / 1.) THF, -15 deg C, 5 min; 2.) THF, -15 deg C, 1h 2: t-butyl thiol / tetrahydrofuran / Ambient temperature; Irradiation View Scheme
参考文献
Tetrahedron, , vol. 44, # 17 p. 5479 - 5486
