1: 1.) n-BuLi / 1.) THF, hexane, 30 min, 2.) THF, hexane, RT, overnight 2: 96 percent / NaH, Pd(PPh3)4 / tetrahydrofuran / -78 - 20 °C 3: 99.9 percent / NaBH4 / methanol / 52 h 4: 100 percent / aq. NaOH / methanol; tetrahydrofuran / Heating 5: 45.9 percent / Me2NCH(OBu-t)2 / toluene / 60 °C 6: 1.) H2, 2.) H2 / 1.) 5percent Pt/C, 2.) 10percent Pd/C / 1.) EtOAc, 25 deg C, 500 psi, 4 h, 2.) EtOH, THF, 60 psi, 4 h View Scheme