4-乙基-2-甲基-1,3-噻唑-5-羧酸合成路线 （共 4 条）
反应条件
potassium hydroxide in ethanol; water 48 h; Ambient temperature;
参考文献
Cornwall, Philip; Dell, Colin P.; Knight, David W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 10 p. 2417 - 2428
反应条件
1: 92 percent / ethanol / 7 h / Heating 2: 58 percent / KOH / ethanol; H2O / 48 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 10 p. 2417 - 2428
反应条件
1: 59 percent / SO2Cl2 / 1.) 18 h, 2.) 3 h under water-pump vacuum 2: 92 percent / ethanol / 7 h / Heating 3: 58 percent / KOH / ethanol; H2O / 48 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 10 p. 2417 - 2428
反应条件
borane-THF in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKAKURA, Nobuyuki; BANNO, Yoshihiro; TERAO, Yoshito; OCHIDA, Atsuko; MORIMOTO, Sachie; KITAMURA, Shuji; TOMATA, Yoshihide; YASUMA, Tsuneo; IKOMA, Minoru; MASUDA, Kei
Patent: WO2013/125732 A1, 2013 ;
Location in patent: Paragraph 0431 ;
