1,2,3,5-四氯-4,6-二氟苯合成路线 （共 10 条）
反应条件
potassium fluoride; tetrakis(diethylamino)phosphonium bromide T=180°C; 24 h; Product distribution / selectivity;
参考文献
BASF Aktiengesellschaft
Patent: WO2006/111583 A1, 2006 ;
Location in patent: Page/Page column 10 ;
反应条件
ammonium hydroxide T=200°C;
参考文献
Yakobson,G.G. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 4 p. 1273 - 1277,1244 - 1247
反应条件
lt;Cp2Cogt;F in tetrahydrofuran
72 h; Ambient temperature;
参考文献
Bennett, Brian K.; Harrison, Roger G.; Richmond, Thomas G.
Journal of the American Chemical Society, 1994 , vol. 116, # 24 p. 11165 - 11166
反应条件
1: KF / various solvent(s) / 12 h / 300 °C
2: 7 percent Chromat. / Cl2 / AlCl3 (25percent) / various solvent(s) / 24 °C
View Scheme
参考文献
Pews, R. G.; Gall, J. A.
Journal of Fluorine Chemistry, 1991 , vol. 52, # 3 p. 307 - 316
反应条件
AlCl3, aluminium chloride; chlorine in 1,2-dichloro-ethane
T=0 - 25°C;
参考文献
BASF Aktiengesellschaft
Patent: WO2006/111583 A1, 2006 ;
Location in patent: Page/Page column 9 ;
反应条件
chlorine; aluminium trichloride in various solvent(s)
T=10°C; Title compound not separated from byproducts;
参考文献
Pews, R. G.; Gall, J. A.
Journal of Fluorine Chemistry, 1991 , vol. 52, # 3 p. 307 - 316
反应条件
1: Br2, Al
2: Cl2 / Irradiation
View Scheme
参考文献
Vorozhtsov,N.N. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1961 , vol. 31, # 5 p. 1674 - 1678,1561 - 1564
反应条件
potassium fluoride; tetrakis(diethylamino)phosphonium bromide
T=220°C; Substitution; P=4940 Torr; 24 h; Product distribution; Further Variations:ReagentsTemperatures;
参考文献
Shipilov; Fedoseev
Russian Journal of Applied Chemistry, 2000 , vol. 73, # 3 p. 556 - 557
反应条件
hexaethylguanidinium chloride; sodium chloride
T=130 - 140°C; 48 h; Product distribution; Further Variations:ReagentsTemperatures;
参考文献
Shipilov; Zolotkova; Igumnov
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 8 p. 1117 - 1120
参考文献
Yakobson,G.G. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1965 , vol. 35, # 1 p. 137 - 141,136 - 140
