1: 3,4-Dihydro-2,2-dimethyl-2H-1-benzopyran With n-butyllithium in hexanes; diethyl ether
1.5 h; Reflux;
2: carbon dioxide in hexanes; diethyl ether
T=20°C;
3: With water in hexanes; diethyl ether
参考文献
Metabolex, Inc.
Patent: US2011/313003 A1, 2011 ;
Location in patent: Page/Page column 26-27 ;
US 20110313003 A1
1: 98 percent / boron trichloride / CH2Cl2 / 2 h / 0 °C
2: 1.) potassium t-butoxide, 2.) pyridine, 3.) m-chloroperbenzoic acid
3: 19 percent / NaOH / H2O / 3 h / other conditions (1M NaOH-EtOH)
View Scheme
参考文献
Baird, Kenneth J.; Grundon, Michael F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1820 - 1825