2-对甲苯基-5-(三氟甲基)吡啶合成路线 （共 7 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in water; toluene T=110°C; Suzuki coupling; 48 h; Inert atmosphere;
参考文献
Chen, Shuming; Tan, Guiping; Wong, Wai-Yeung; Kwok, Hoi-Sing
Advanced Functional Materials, 2011 , vol. 21, # 19 p. 3785 - 3793
反应条件
copper; isopentyl nitrite in acetonitrile T=0 - 15°C; Sandmeyer Reaction; 8 h; Schlenk techniqueInert atmosphere;
参考文献
Dai, Jian-Jun; Fang, Chi; Xiao, Bin; Yi, Jun; Xu, Jun; Liu, Zhao-Jing; Lu, Xi; Liu, Lei; Fu, Yao
Journal of the American Chemical Society, 2013 , vol. 135, # 23 p. 8436 - 8439
反应条件
1: 57 percent / ethanol / 0.25 h / Heating 2: 84 percent / POCl3, N,N-diethylaniline / 2 h / Ambient temperature 3: 91 percent / Et3N, H2 / Pd-C / benzene 4: 72 percent / toluene / 4 h / Heating View Scheme
参考文献
Katagiri; Watanabe; Kaneko
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 9 p. 3354 - 3372
反应条件
1: 84 percent / POCl3, N,N-diethylaniline / 2 h / Ambient temperature 2: 91 percent / Et3N, H2 / Pd-C / benzene 3: 72 percent / toluene / 4 h / Heating View Scheme
参考文献
Katagiri; Watanabe; Kaneko
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 9 p. 3354 - 3372
反应条件
1: 91 percent / Et3N, H2 / Pd-C / benzene 2: 72 percent / toluene / 4 h / Heating View Scheme
参考文献
Katagiri; Watanabe; Kaneko
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 9 p. 3354 - 3372
反应条件
in toluene 4 h; Heating;
参考文献
Katagiri; Watanabe; Kaneko
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 9 p. 3354 - 3372
反应条件
1.1: sodium carbonate / toluene; ethanol / 0.5 h / 20 °C / |Inert atmosphere 1.2: 24 h / |Inert atmosphere; |Reflux 2.1: copper; isopentyl nitrite / acetonitrile / 8 h / 0 - 15 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Dai, Jian-Jun; Fang, Chi; Xiao, Bin; Yi, Jun; Xu, Jun; Liu, Zhao-Jing; Lu, Xi; Liu, Lei; Fu, Yao
Journal of the American Chemical Society, 2013 , vol. 135, # 23 p. 8436 - 8439
