2-去氨基-2,3-二甲基-N(10)-炔丙基-5,8-二去氮杂叶酸合成路线 （共 4 条）
反应条件
1: 76.8 percent / aq. HCl / 0.25 h 2: 35 percent / 1,3-dibromo-5,5-dimethylhydantoin / CCl4; CHCl3 / Heating; Irradiation 3: 87 percent / MgO / N,N-dimethyl-acetamide / 18 h / 90 - 100 °C View Scheme
参考文献
Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289
反应条件
1: 87 percent / MgO / N,N-dimethyl-acetamide / 18 h / 90 - 100 °C View Scheme
参考文献
Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289
反应条件
1: 35 percent / 1,3-dibromo-5,5-dimethylhydantoin / CCl4; CHCl3 / Heating; Irradiation 2: 87 percent / MgO / N,N-dimethyl-acetamide / 18 h / 90 - 100 °C View Scheme
参考文献
Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289
反应条件
Yield given. Multistep reaction;
参考文献
Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289
