NΑ-FMOC-NΩ-(2,2,5,7,8-五甲基苯并二氢吡喃-6-磺酰基)-L-精氨酸合成路线 （共 9 条）
反应条件
sodium carbonate in N,N-dimethyl-formamide 1 h;
参考文献
Tetrahedron, , vol. 47, # 32 p. 6353 - 6370
反应条件
1: 53 percent / chlorosulphonic acid / CHCl3 / 1.) -5 deg C, 15 min 2.) -5 deg C -> rt, 1 h 2: 3.2 M sodium hydroxide / acetone / 1.) 0 deg C, 2 h 2.) rt, 2 h 3: H2 / 10percent Pd/C / methanol 4: 89 percent / 6percent aq. sodium carbonate / dimethylformamide / 1 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 32 p. 6353 - 6370
反应条件
1: 44 percent / ZnCl2 / acetic acid / 1.) 23 deg C, 12 h 2.) 150 deg C, 7 h 2: 53 percent / chlorosulphonic acid / CHCl3 / 1.) -5 deg C, 15 min 2.) -5 deg C -> rt, 1 h 3: 3.2 M sodium hydroxide / acetone / 1.) 0 deg C, 2 h 2.) rt, 2 h 4: H2 / 10percent Pd/C / methanol 5: 89 percent / 6percent aq. sodium carbonate / dimethylformamide / 1 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 32 p. 6353 - 6370
反应条件
1: 3.2 M sodium hydroxide / acetone / 1.) 0 deg C, 2 h 2.) rt, 2 h 2: H2 / 10percent Pd/C / methanol 3: 89 percent / 6percent aq. sodium carbonate / dimethylformamide / 1 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 32 p. 6353 - 6370
反应条件
1: H2 / 10percent Pd/C / methanol 2: 89 percent / 6percent aq. sodium carbonate / dimethylformamide / 1 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 32 p. 6353 - 6370
反应条件
1: 44 percent / ZnCl2 / acetic acid / 1.) 23 deg C, 12 h 2.) 150 deg C, 7 h 2: 53 percent / chlorosulphonic acid / CHCl3 / 1.) -5 deg C, 15 min 2.) -5 deg C -> rt, 1 h 3: 3.2 M sodium hydroxide / acetone / 1.) 0 deg C, 2 h 2.) rt, 2 h 4: H2 / 10percent Pd/C / methanol 5: 89 percent / 6percent aq. sodium carbonate / dimethylformamide / 1 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 32 p. 6353 - 6370
反应条件
benzotriazol-1-ol; dicyclohexyl-carbodiimide in acetonitrile T=20°C; 16 h;
参考文献
Zhang, Han-Cheng; Hoekstra, William J.; Maryanoff, Bruce E.; McComsey, David F.
Patent: US2003/224999 A1, 2003 ;
Location in patent: Page 13-14; 23 ;
参考文献
Green, J.; Ogunjobi, O. M.; Ramage, R.; Stewart, A. S. J.
Tetrahedron Letters, 1988 , vol. 29, # 34 p. 4341 - 4344
反应条件
1.1: i-BuOCOCl; NMM / tetrahydrofuran / 0.33 h / -16 °C
1.2: 40 percent / tetrahydrofuran; diethyl ether / 1 h
2.1: 50 percent / AgO2CCF3; NMM / tetrahydrofuran; H2O / 22.5 h
View Scheme
参考文献
Gelman, Michael A.; Richter, Sara; Cao, Hong; Umezawa, Naoki; Gellman, Samuel H.; Rana, Tariq M.
Organic Letters, 2003 , vol. 5, # 20 p. 3563 - 3565
