(S)-5-甲基吗啉-3-酮合成路线 （共 5 条）
反应条件
potassium tert-butylate in dichloromethane; isopropyl alcohol T=0°C; TemperatureTime;
参考文献
SPHAERA PHARMA PVT. LTD.; DUGAR, Sundeep; MAHAJAN, Dinesh; HOLLINGER PETER, Frank; SHARMA, Amit; TRIPATHI, Vinayak; KUILA, Bilash
Patent: WO2014/16849 A2, 2014 ;
Location in patent: Page/Page column 126; 127 ;
反应条件
1: (S)-2-aminopropanol With sodium hydride in toluene T=0 - 20°C; 0.5 h; 2: chloroacetic acid ethyl ester in toluene 20 h; Heating / reflux; 3: With ammonium chloride in toluene T=20°C; 0.333333 h;
参考文献
AMR TECHNOLOGY, INC.
Patent: US2008/255114 A1, 2008 ;
Location in patent: Page/Page column 17 ;
反应条件
1: (S)-2-aminopropanol With sodium hydride in tetrahydrofuran 0.583333 h; 2: 2-chloro-1-ethanol acetate in tetrahydrofuran 3.5 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1785418 A1, 2007 ;
Location in patent: Page/Page column 147-148 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; Inert atmosphere; Temperature;
参考文献
SPHAERA PHARMA PVT. LTD.; DUGAR, Sundeep; MAHAJAN, Dinesh; HOLLINGER PETER, Frank; SHARMA, Amit; TRIPATHI, Vinayak; KUILA, Bilash
Patent: WO2014/16849 A2, 2014 ;
Location in patent: Page/Page column 126; 127; 128 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=25°C;
参考文献
Norman, Bryan H.; Kroin, Julian S.
Journal of Organic Chemistry, 1996 , vol. 61, # 15 p. 4990 - 4998
