1: 1) TFA, 2) 1-hydroxybenzotriazole, N-methylmorpholine / 1) O deg C, 10 min, 2) DMF, 2 h 3: 1) 30percent piperidine, 2) TFA, m-cresol / 1) DMF, 12 h, room temperature, 2) 0 deg C, 10 min View Scheme

piperidine; N,N-dimethyl-formamide 12 h; Ambient temperatureother reagent; Product distribution;

Multi-step reaction with 2 steps 1: 1) TFA, 2) 1-hydroxybenzotriazole, N-methylmorpholine / 1) O deg C, 10 min, 2) DMF, 2 h