1: With copper(l) iodide in acetonitrile T=20°C; 0.166667 h; Inert atmosphere; 2: With cesium fluoride in acetonitrile 2 h; Inert atmosphereReflux;

1: With copper(l) iodide in acetonitrile T=20°C; 0.166667 h; Inert atmosphere; 2: With cesium fluoride in acetonitrile 2 h; Inert atmosphereReflux;

1: TBHP/VO(acac)2 / acetone 2: 50 percent / Ti(OiPr)4, (+)-DET, TBHP / CH2Cl2 / 40 h / -20 °C 3: 90 percent / Et4NF / acetonitrile / Ambient temperature View Scheme

1: 13 percent / MCPBA, CaCO3 / CH2Cl2 / -30 °C 2: TBHP, Ti(O-i-Pr)4, ethyl L-tartrate / CH2Cl2; 2,2,4-trimethyl-pentane / 40 h / -20 °C 3: tetraethylammonium fluoride hydrate / acetonitrile / 3 h / Ambient temperature View Scheme

Multi-step reaction with 2 steps 1: TBHP/VO(acac)2 / acetone2: 50 percent / Ti(OiPr)4, (+)-DET, TBHP / CH2Cl2 / 40 h / -20 °C