反应条件
Multi-step reaction with 4 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 18 h / 0 - 25 °C / |Large scale1.2: 5 h / 0 - 25 °C / |Large scale1.3: 0.5 h / 0 - 15 °C / |Large scale2.1: N-iPr-L-Pro; diethylzinc / tetrahydrofuran / 20 °C / |Large scale2.2: |Large scale3.1: palladium diacetate; 1,4-diaza-bicyclo[2.2.2]octane / methanol / 3 h / 65 °C / |Large scale4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol / 2 h / 50 - 55 °C / |Large scale
参考文献
Reeves, Jonathan T.; Fandrick, Daniel R.; Tan, Zhulin; Song, Jinhua J.; Rodriguez, Sonia; Qu, Bo; Kim, Soojin; Niemeier, Oliver; Li, Zhibin; Byrne, Denis; Campbell, Scot; Chitroda, Ashish; Decroos, Phil; Fachinger, Thomas; Fuchs, Victor; Gonnella, Nina C.; Grinberg, Nelu; Haddad, Nizar; Jaeger, Burkhard; Lee, Heewon; Lorenz, Jon C.; Ma, Shengli; Narayanan, Bikshandarkoil A.; Nummy, Larry J.; Premasiri, Ajith; Roschangar, Frank; Sarvestani, Max; Shen, Sherry; Spinelli, Earl; Sun, Xiufeng; Varsolona, Richard J.; Yee, Nathan; Brenner, Michael; Senanayake, Chris H. Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 3616 - 3635