N-[2-溴-5-(苯甲氧基)苯基]氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
in 1,4-dioxane T=105°C; 10 h;
参考文献
Boger, Dale L.; Wysocki Jr., Ronald J.; Ishizaki, Takayoshi
Journal of the American Chemical Society, 1990 , vol. 112, # 13 p. 5230 - 5240
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Boger; Wysocki Jr.
Journal of Organic Chemistry, 1989 , vol. 54, # 6 p. 1238 - 1240
反应条件
1: 42 percent / N-bromosuccinimide, H2SO4 / tetrahydrofuran / 10 h / -78 °C 2: 85 percent / dioxane / 10 h / 105 °C View Scheme
参考文献
Boger, Dale L.; Wysocki Jr., Ronald J.; Ishizaki, Takayoshi
Journal of the American Chemical Society, 1990 , vol. 112, # 13 p. 5230 - 5240
反应条件
N-bromosuccinmide; sulfuric acid
参考文献
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Patent: WO2005/32594 A2, 2005 ;
Location in patent: Page/Page column 29 ;
反应条件
1: 68 percent / NaH / tetrahydrofuran; dimethylformamide / 3 h / 25 °C 2: 91 percent / Bu3SnH, AIBN / benzene / 3 h / 80 °C 3: 1.) ozone, 2.) NaBH4 / 1.) EtOH, -78 deg C, 3 min, 2.) EtOH, H2O, -78 to 24 deg C, 4 h 4: 89 percent / Et3N / CH2Cl2 / 0.42 h / 0 °C 5: 75 percent / H2 / 10percent Pd/C / tetrahydrofuran / 7 h / 24 °C / 760 Torr 6: 100 percent / HCl / ethyl acetate / 0.17 h / 24 °C 7: 71 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide, K2CO3 / dimethylformamide / 20 h / 24 °C 8: 91 percent / NaH / tetrahydrofuran; dimethylformamide / 0.42 h / 24 °C View Scheme
参考文献
Boger, Dale L.; Wysocki Jr., Ronald J.; Ishizaki, Takayoshi
Journal of the American Chemical Society, 1990 , vol. 112, # 13 p. 5230 - 5240
反应条件
1: 68 percent / NaH / tetrahydrofuran; dimethylformamide / 3 h / 25 °C 2: 91 percent / Bu3SnH, AIBN / benzene / 3 h / 80 °C 3: 1.) ozone, 2.) NaBH4 / 1.) EtOH, -78 deg C, 3 min, 2.) EtOH, H2O, -78 to 24 deg C, 4 h 4: 89 percent / Et3N / CH2Cl2 / 0.42 h / 0 °C 5: 75 percent / H2 / 10percent Pd/C / tetrahydrofuran / 7 h / 24 °C / 760 Torr 6: 100 percent / HCl / ethyl acetate / 0.17 h / 24 °C 7: 84 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide, Et3N / dimethylformamide / 45 h / 24 °C 8: 90 percent / NaH / tetrahydrofuran / 0.42 h / 24 °C View Scheme
参考文献
Boger, Dale L.; Wysocki Jr., Ronald J.; Ishizaki, Takayoshi
Journal of the American Chemical Society, 1990 , vol. 112, # 13 p. 5230 - 5240
反应条件
1: 68 percent / NaH / tetrahydrofuran; dimethylformamide / 3 h / 25 °C
2: 91 percent / Bu3SnH, AIBN / benzene / 3 h / 80 °C
3: 1.) ozone, 2.) NaBH4 / 1.) EtOH, -78 deg C, 3 min, 2.) EtOH, H2O, -78 to 24 deg C, 4 h
4: 89 percent / Et3N / CH2Cl2 / 0.42 h / 0 °C
5: 75 percent / H2 / 10percent Pd/C / tetrahydrofuran / 7 h / 24 °C / 760 Torr
6: 100 percent / HCl / ethyl acetate / 0.17 h / 24 °C
7: 71 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide, K2CO3 / dimethylformamide / 20 h / 24 °C
View Scheme
参考文献
Boger, Dale L.; Wysocki Jr., Ronald J.; Ishizaki, Takayoshi
Journal of the American Chemical Society, 1990 , vol. 112, # 13 p. 5230 - 5240
