5-苯基-2-羟基-1,3,4-噁二唑合成路线 （共 27 条）
反应条件
1: (i) POCl3, HCl, (ii) PCl5, HCl 2: ethanol View Scheme
参考文献
Golfier,M.; Milcent,R.
Journal of Heterocyclic Chemistry, 1973 , vol. 10, p. 989 - 991
反应条件
(i) Ag2O, benzene, (ii) /BRN= 505934/, MeCN; Multistep reaction;
参考文献
Golfier,M.; Milcent,R.
Bulletin de la Societe Chimique de France, 1973 , p. 254 - 258
反应条件
(i) Ag2O, benzene, (ii) /BRN= 505934/, MeCN; Multistep reaction;
参考文献
Golfier,M.; Milcent,R.
Bulletin de la Societe Chimique de France, 1973 , p. 254 - 258
反应条件
in various solvent(s)
T=70°C; 48 h;
参考文献
Saegusa, Yasuo; Harada, Shigeo; Nakamura, Shigeo
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1337 - 1342
反应条件
sodium hydride
1.) DMF, 40-60 deg C, 15 min, 2.) DMF, 80-100 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Chau, Francois; Malanda, Jean-Claude; Milcent, Rene
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 5 p. 1603 - 1606
反应条件
1: 96 percent / sodium hydride / dimethylformamide / 2 h / 25 °C
2: 88 percent / sodium hydride / dimethylformamide / 3 h
3: 700 °C / 0.01 Torr
View Scheme
参考文献
Padwa,A.; Caruso,T.; Nahm,S.
Journal of the American Chemical Society, 1982 , vol. 104, p. 2865
反应条件
sodium hydride
1.) DMF, 40-60 deg C, 15 min, 2.) DMF, 80-100 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Chau, Francois; Malanda, Jean-Claude; Milcent, Rene
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 5 p. 1603 - 1606
反应条件
in various solvent(s)
T=150°C; 24 h;
参考文献
Saegusa, Yasuo; Harada, Shigeo; Nakamura, Shigeo
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1337 - 1342
反应条件
in various solvent(s)
T=150 - 160°C; 5 h;
参考文献
Chau, Nguyen; Saegusa, Yasuo; Iwakura, Yoshio
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 541 - 544
反应条件
(i) Ag2O, benzene, (ii) /BRN= 969135/, MeCN; Multistep reaction;
参考文献
Yan, Xu; Zhou, Shuo; Wang, Yuanqiang; Ge, Zemei; Cheng, Tieming; Li, Runtao
Tetrahedron, 2012 , vol. 68, # 38 p. 7978 - 7983
