N,N-二甲基-3-苯基丙烷-1-胺合成路线 (共 45 条)
反应条件
1: With formic acid 18 h; Reflux; 2: With sodium hydrogencarbonate in water
参考文献
PROBIODRUG AG
Patent: US2011/92501 A1, 2011 ;
Location in patent: Page/Page column 140-141 ;
反应条件
pentacarbonyliron(0); 1,1,3,3-tetramethyldisiloxane in toluene T=20°C; Inert atmosphereIrradiation;
参考文献
Sunada, Yusuke; Kawakami, Hiroko; Imaoka, Tsuyoshi; Motoyama, Yukihiro; Nagashima, Hideo
Angewandte Chemie - International Edition, 2009 , vol. 48, # 50 p. 9511 - 9514
反应条件
[Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; bis[2-(diphenylphosphino)phenyl] ether in toluene T=20°C; Inert atmosphereReflux;
参考文献
Hamid, M. Haniti S. A.; Allen, C. Liana; Lamb, Gareth W.; Maxwell, Aoife C.; Maytum, Hannah C.; et al.
Journal of the American Chemical Society, 2009 , vol. 131, p. 1766 - 1774
反应条件
1: in tetrahydrofuran T=25°C; 0.5 h; 2: With hydrogenchloride in tetrahydrofuran; methanol T=65°C; 5 h; Further stages.;
参考文献
Thomas, Shannon; Huynh, Tai; Enriquez-Rios, Vanessa; Singaram, Bakthan
Organic Letters, 2001 , vol. 3, # 24 p. 3915 - 3918
反应条件
hydrogen; RhH(CO)(triphenylphosphine)3 in benzene T=80°C; P=76000 Torr; 24 h; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 59, # 23 p. 7125 - 7127
反应条件
polymethylhydrosiloxane; dihydrogen hexachloroplatinate in tetrahydrofuran T=90°C; 3 h;
参考文献
Tetrahedron Letters, , vol. 47, # 35 p. 6173 - 6177
反应条件
1: With titanium(IV) isopropylate in methanol T=20°C; Addition; 2: With sodium tetrahydroborate in methanol T=20°C; Reduction; 1.5 h;
参考文献
Bhattacharyya, Sukanta
Synthetic Communications, 2000 , vol. 30, # 11 p. 2001 - 2008
反应条件
zinc(II) iodide in dichloromethane T=20°C; 36 h;
参考文献
Miura; Ootsuka; Suda; Nishikori; Hosomi
Synlett, 2001 , # 10 p. 1617 - 1619
反应条件
in ethanol 5 h; Heating;
参考文献
Glennon; Salley Jr.; Steinsland; Nelson
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 678 - 683
反应条件
in methanol 45 h; Ambient temperatureIrradiation;
参考文献
Partali, Vassilia; Jolidon, Synese; Hansen, Hans-Juergen
Helvetica Chimica Acta, 1985 , vol. 68, p. 1952 - 1960