2-甲基-3,4,6-三氟苯甲酸合成路线 （共 14 条）
反应条件
1: 99 percent / CsF, H2O / dimethylformamide / Ambient temperature 2: 61 percent / 6 N HCl / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 27, # 6 p. 1609 - 1616
反应条件
1: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1 h, 2) up to 0 deg C 2: 1) 2.3 M n-BuLi / 1) ether, -78 deg C, 5 min, 2) ether, up to room temp. 3: 89 percent / CsF / acetonitrile / Ambient temperature View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 27, # 6 p. 1609 - 1616
反应条件
Hostarex A 327 T=150°C; 2 h;
参考文献
Clariant GmbH
Patent: US6362365 B1, 2002 ;
Location in patent: Page column 13-16 ;
反应条件
1: COCl2, DMF / CH2Cl2 / 2 h / Ambient temperature 2: 1) n-BuLi, bipyridyl / 1) THF, -35 -> -5 deg C, 2) THF, -78 deg C, 1 h 3: 98 percent / acetic anhydride / 3 h / Heating 4: ethanol / a) 5 - 15 deg C, 90 min, b) 2 h , room temp. 5: 1) 60percent NaH, 2) 6 M HCl / 1) THF, room temp., 2) reflux, 3 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 27, # 6 p. 1609 - 1616
