3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1: 73 percent / Al2O3 / CH2Cl2 / 16 h / 20 °C 2: BBr3 / CH2Cl2 / 24 h / 0 - 20 °C View Scheme
参考文献
Bolek, David; Guetschow, Michael
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 7 p. 1399 - 1403
反应条件
1: potassium hydroxide / methanol; water / Reflux 2: boron tribromide / dichloromethane / 0 - 20 °C View Scheme
参考文献
Haudecoeur, Romain; Ahmed-Belkacem, Abdelhakim; Yi, Wei; Fortune, Antoine; Brillet, Rozenn; Belle, Catherine; Nicolle, Edwige; Pallier, Coralie; Pawlotsky, Jean-Michel; Boumendjel, Ahcene
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5395 - 5402
反应条件
1: acetic acid; ammonium acetate / 20 - 120 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / |Reflux 3: dichloromethane / 1 h / 20 °C 4: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / |Inert atmosphere; |Reflux View Scheme
参考文献
Crestey, Francois; Jensen, Anders A.; Borch, Morten; Andreasen, Jesper Tobias; Andersen, Jacob; Balle, Thomas; Kristensen, Jesper Langgaard
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9673 - 9682
反应条件
ammonium acetate in ethylene glycol microwave irradiation; atmospheric pressure;
参考文献
Tu, Shujiang; Li, Tuanjie; Shi, Feng; Wang, Qian; Zhang, Jinpeng; Xu, Jianing; Zhu, Xiaotong; Zhang, Xiaojing; Zhu, Songlei; Shi, Daqing
Synthesis, 2005 , # 18 art. no. F08805SS, p. 3045 - 3050
反应条件
1: NH4OAc; AcOH 2: LiAlH4 3: NaOH / CH2Cl2 View Scheme
参考文献
Silveira, Claudio C.; Bernardi, Carmem R.; Braga, Antonio L.; Kaufman, Teodoro S.
Tetrahedron Letters, 1999 , vol. 40, # 27 p. 4969 - 4972
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane 24 h; Ambient temperature; Yield given;
参考文献
Chiba, Kazuhiro; Sonoyama, Junko; Tada, Masahiro
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 12 p. 1435 - 1443
反应条件
1: Methyltriphenylphosphonium bromide With phenyllithium; lithium bromide in tetrahydrofuran; anhydrous butyl ether T=-78 - 20°C; 0.166667 h; Inert atmosphere; 2: With phenyllithium in tetrahydrofuran; anhydrous butyl ether T=-78 - 20°C; 0.5 h; Inert atmosphere; 3: 3,4-dimethoxy-benzaldehyde; acetaldehyde regioselective reaction; Further stages;
参考文献
Hodgson, David M.; Persaud, Rosanne S. D.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 39 p. 7949 - 7951
反应条件
1: 1.28 g / aq. NaOH / 0.5 h / Ambient temperature 2: NaBH4 / methanol / Ambient temperature View Scheme
参考文献
Singh, Kamaljeet; Staig, Shannon J.; Weaver, Jimmie D.
Journal of the American Chemical Society, 2014 , vol. 136, # 14 p. 5275 - 5278
反应条件
1: 76 percent / methanol / -10 °C 2: 86 percent / xylene / Heating 3: 85 percent / aq. NaOH / Heating 4: 61 percent / Cu; quinoline / Heating 5: 86 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
sodium ethanolate in ethanol T=20°C;
参考文献
KABUSHIKI KAISHA YAKULT HONSHA
Patent: EP1864972 A1, 2007 ;
Location in patent: Page/Page column 12; 21 ;
