3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1: NH4OAc / acetic acid 2: Fe, FeCl3, aq. HCl 3: LiAlH4 / diethyl ether View Scheme
参考文献
Morgan,P.H.; Beckett,A.H.
Tetrahedron, 1975 , vol. 31, p. 2595 - 2601
参考文献
Ambros, Reinhard; Schneider, Martin R.; Angerer, Silvia von
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 153 - 160
反应条件
1: o-hydroxyacetophenone With sodium hydride in tetrahydrofuran; mineral oil Inert atmosphere; 2: 3,4-dimethoxy-benzaldehyde in tetrahydrofuran; mineral oil T=20°C; Aldol condensation; 16.25 h; 3: With hydrogenchloride in tetrahydrofuran; water; mineral oil
参考文献
Sagrera, Gabriel; Bertucci, Ana; Vazquez, Alvaro; Seoane, Gustavo
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 10 p. 3060 - 3073
反应条件
1H-imidazole; 18-crown-6 ether; sodium hydride in tetrahydrofuran; benzene 20 h;
参考文献
Katagi, Toyoshi; Shirota, Taeko; Kashiwagi, Masako; Hayashi, Kayo
Heterocycles, 1981 , vol. 15, # 1 p. 493 - 494
反应条件
1: ethanol; aq. NaOH solution 2: methanol; acetic acid 3: acetic acid; sulfuric acid 4: aq.-ethanolic NaOH-solution 5: amalgamated zinc; aqueous hydrochloric acid; toluene / weiteres Reagenz: Essigsaeure View Scheme
参考文献
Richardson et al.
Journal of the Chemical Society, 1937 , p. 835,839
反应条件
in benzene 3 h; Heating;
参考文献
Landais; Robin
Tetrahedron, 1992 , vol. 48, # 35 p. 7185 - 7196
反应条件
iodine; potassium carbonate; potassium iodide in water T=90°C; 0.5 h;
参考文献
Gogoi, Pranjal; Konwar, Dilip
Tetrahedron Letters, 2006 , vol. 47, # 1 p. 79 - 82
反应条件
1: water / 0.03 h / Ultrasound irradiation 2: N-bromosuccinmide / water / 0.25 h / 65 - 70 °C / Ultrasound irradiation View Scheme
参考文献
Sant' Anna, Gabriela da S.; Machado, Pablo; Sauzem, Patricia D.; Rosa, Fernanda A.; Rubin, Maribel A.; Ferreira, Juliano; Bonacorso, Helio G.; Zanatta, Nilo; Martins, Marcos A.P.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 546 - 549
反应条件
1: 80 percent / KSCN; Triton X-405 / 7 h / 180 °C 2: 8 h / 70 °C View Scheme
参考文献
Bhattacharya, Apurba; Patel, Nitin C.; Vasques, Tomas; Tichkule, Ritesh; Parmar, Gaurang; Wu, Jiejun
Tetrahedron Letters, 2006 , vol. 47, # 4 p. 565 - 567
反应条件
1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C 2: sodium tetrahydroborate; methanol; pyridine / 9 h / 100 °C 3: N-bromosuccinmide / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C 4: sodium amide / ammonia / 2 h / 20 °C / |liquid NH3 View Scheme
参考文献
LES LABORATOIRES SERVIER; CARRANZA, Maria Del Pilar; GARCIA ARANDA, Maria Isabel; GONZALEZ, José Lorenzo; SANCHEZ, Frédéric
Patent: US2014/163220 A1, 2014 ;
