3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1: triphenyl-methyl-phosphonium iodide With potassium tert-butylate in tetrahydrofuran 1 h; Inert atmosphere; 2: 3,4-dimethoxy-benzaldehyde in tetrahydrofuran T=25°C; Wittig reaction; 24 h; Inert atmosphere;
参考文献
Albert, Sabrina; Horbach, Ralf; Deising, Holger B.; Siewert, Bianka; Csuk, Rene
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5155 - 5166
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane; cyclohexane T=0°C; 4 h; Inert atmosphere; 2: 3,4-dimethoxy-benzaldehyde in tetrahydrofuran; hexane; cyclohexane T=20°C; Wittig Olefination; 10 h; Inert atmosphere;
参考文献
Falk, Anna; Goederz, Anna-Lena; Schmalz, Hans-Guenther
Angewandte Chemie - International Edition, 2013 , vol. 52, # 5 p. 1576 - 1580
Angew. Chem., 2013 , vol. 125, # 5 p. 1617 - 1621,5
反应条件
pyridine; acetic acid T=130°C; Knoevenagel-Doebner reaction; 0.133333 h; microwave irradiation;
参考文献
Tetrahedron, , vol. 63, # 4 p. 960 - 965
反应条件
und Destillation des Reaktionsprodukts;
参考文献
Frank et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1368
Org. Synth. Coll. Vol., 1963 , vol. IV, p. 451
反应条件
in 1,4-dioxane; water Inert atmosphere;
参考文献
Pouilhes, Annie; Baltaze, Jean-Pierre; Kouklovsky, Cyrille
Synlett, 2013 , vol. 24, # 14 art. no. ST-2013-D0541-L, p. 1805 - 1808
反应条件
n-butyllithium Yield given. Multistep reaction;
参考文献
Seitz, David E.; Zapata, Antonio
Tetrahedron Letters, 1980 , vol. 21, p. 3451 - 3454
反应条件
HMDS 1.) THF, r.t., 30 min, 2.) THF, r.t., 20 min; Yield given. Multistep reaction;
参考文献
Redeuilh,G. et al.
Bulletin de la Societe Chimique de France, 1973 , p. 2667 - 2668
反应条件
1: NaBH4 / methanol / 20 °C 2: SOCl2 / dioxane / 20 °C View Scheme
参考文献
Paul, D. Brenton
Australian Journal of Chemistry, 1984 , vol. 37, # 4 p. 893 - 901
反应条件
ammonium acetate in acetic acid; benzene Heating;
参考文献
Chakrabarti,P.M. et al.
Tetrahedron, 1969 , vol. 25, p. 2781 - 2785
反应条件
1: 1) reflux; 2) -10 deg C, 5 min; 3) room temp., 15 h 2: 1) n-butyllithium / 1) THF, -78 deg C, 15 min; 2) THF, 0.5 h at -78 deg C, then 3 h at room temp. 3: 64 mg / TiCl4 / CH2Cl2 / 1.) -78 deg C, 15 min, 2.) room temp. 3 h View Scheme
参考文献
Falck, J.R.; Manna, Sukumar
Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3742 - 3745
