3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
n-butyllithium; 1,2,2-trichloro-1,1,2-trichloro-ethane; N,N,N'-trimethyl-ethylenediamine 1.) THF, from -70 deg C to -30 deg C, 8 h, 2.) THF, RT, 3 h; Yield given. Multistep reaction;
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
反应条件
1: chloroform; chlorine / 40 - 50 °C 2: pyridine; aqueous potassium permanganate solution View Scheme
参考文献
Raiford; Floyd
Journal of Organic Chemistry, 1943 , vol. 8, p. 358,363,365
反应条件
1: (i), (ii) aq. K2CO3, acetone, (iii) Na-Hg, H2O 2: aq. HCl View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 52, # 16 p. 2873 - 2879
反应条件
n-butyllithium in tetrahydrofuran T=-78°C; 3 h;
参考文献
Journal of Organic Chemistry, , vol. 56, # 4 p. 1381 - 1386
反应条件
pyridine; ammonium acetate in toluene
参考文献
Ayres,D.C.; Mhasalkar,S.E.
Journal of the Chemical Society [Section] C: Organic, 1968 , p. 1885 - 1887
参考文献
Schiemenz,G.P.; Engelhard,H.
Chemische Berichte, 1961 , vol. 94, p. 578 - 584
反应条件
manganese; titanium tetrachloride in tetrahydrofuran T=-10°C; 0.5 h; Inert atmosphere; optical yield given as percent de;
参考文献
Duan, Xin-Fang; Feng, Jian-Xia; Zi, Guo-Fu; Zhang, Zhan-Bin
Synthesis, 2009 , # 2 p. 277 - 282
反应条件
1: Br2 / methanol 2: NaBH4 3: NBS; Ph3P View Scheme
参考文献
LES LABORATOIRES SERVIER; CARRANZA, Maria Del Pilar; GARCIA ARANDA, Maria Isabel; GONZALEZ, José Lorenzo; SANCHEZ, Frédéric
Patent: US2014/163220 A1, 2014 ;
反应条件
1: 88.4 percent / NH2OH*HCl, sodium hydroxide / aq. ethanol; H2O / 3 h / Ambient temperature 2: 78.5 percent / acetic anhydride / 0.5 h / Heating 3: 75 percent / hydrogen sulphide gas, triethylamine, pyridine / 6 h / Ambient temperature View Scheme
参考文献
Khadse, B. G.; Lokhande, S. R.; Bhamaria, R. P.; Prabhu, S. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 856 - 860
反应条件
1: in methanol T=20°C; 0.25 h; Inert atmosphere; 2: With sodium tetrahydroborate in methanol T=20°C; 1 h; Inert atmosphere;
参考文献
Castaing, Matthias; Wason, Sacha L.; Estepa, Beatriz; Hooper, Joel F.; Willis, Michael C.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 50 p. 13280 - 13283
Angew. Chem., 2013 , vol. 125, # 50 p. 13522 - 13525,4
