3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
methylamine; palladium monocarbide in ethanol; water; toluene
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US4987235 A1, 1991 ;
反应条件
titanium(IV) isopropylate; sodium tetrahydroborate; triethylamine 1.) EtOH, 25 deg C, 9 h, 2.) EtOH, 25 deg C, 8 h; Yield given. Multistep reaction;
参考文献
Neidigh, Kurt A.; Avery, Mitchell A.; Williamson, John S.; Bhattacharyya, Sukanta
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 16 p. 2527 - 2531
参考文献
Noller; Kneeland
Journal of the American Chemical Society, 1946 , vol. 68, p. 201
反应条件
manganese; titanium tetrachloride in tetrahydrofuran T=-10°C; 0.5 h; Inert atmosphere; optical yield given as percent de;
参考文献
Duan, Xin-Fang; Feng, Jian-Xia; Zi, Guo-Fu; Zhang, Zhan-Bin
Synthesis, 2009 , # 2 p. 277 - 282
反应条件
1: p-toluenesulfonic acid / methanol / 1 h / Heating 2: 1) n-butyllithium / 1) ether, ice-water cooling, 1 h, 2) dry ice-acetone bath View Scheme
参考文献
Napolitano, Elio; Giannone, Enrico; Fiaschi, Rita; Marsili, Antonio
Journal of Organic Chemistry, 1983 , vol. 48, # 21 p. 3653 - 3657
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 95 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 88 percent / tetrahydrofuran; hexane / 3 h / -78 °C 3.1: 87 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr 4.1: 97 percent / trifluoroacetic acid / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
AcOF; mercury(II) trifluoroacetate 1.) ethanol, room temperature, 72 h, 2.) CHCl3/freon, room temperature; Yield given. Multistep reaction;
参考文献
Luxen, A.; Barrio, J.R.
Tetrahedron Letters, 1988 , vol. 29, # 13 p. 1501 - 1504
反应条件
1: (methoxymethyl)-triphenylphosphonium chloride With potassium tert-butylate in tetrahydrofuran T=0°C; 0.5 h; 2: 3,4-dimethoxy-benzaldehyde in tetrahydrofuran T=20°C; 12 h; 3: With formic acid in dichloromethane T=20°C; 72 h; Further stages.;
参考文献
Pedrosa; Andres; Iglesias
Journal of Organic Chemistry, 2001 , vol. 66, # 1 p. 243 - 250
反应条件
1: 73 percent / NaOMe / methanol / -5 deg C, 2 h then 20 deg C, 3 h 2: 1) NaOMe/MeOH, 2) acetic acid / 1) benzene, H2O, Et2O, 5-10 deg C, 3 h, 2) benzene, reflux, 3h View Scheme
参考文献
Haridas, K.; Dev, Sukh
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 1018 - 1020
反应条件
ethanol; ammonia; nickel T=80°C; P=73550.8 Torr; Hydrogenation;
参考文献
Basappa; Doreswamy; Mahendra; Mantelingu; Sridhar; Prasad, J. Shashidhara; Rangappa
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 1 p. 148 - 151
