3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1: diethyl ether 2: zinc; hydrochloric acid; water 3: Raney nickel; dioxane / 150 °C / 60311.6 Torr / Hydrogenation View Scheme
参考文献
Sugimoto
Yakugaku Zasshi, 1956 , vol. 76, p. 1045
Chem.Abstr., 1957 , p. 3598
反应条件
1: Cl2 / CH2Cl2 2: BBr3 4: ZnI2 5: LiAlH4 6: H2 / Pd/C View Scheme
参考文献
Squier; Van der Schyf; Oliver; Venter
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 3 p. 457 - 460
反应条件
1: sodium methoxide / methanol / 4 h / -15 °C 2: xylene / 0.25 h / Heating 3: 80 percent / BBr3 / CH2Cl2 / 4 h / -40 °C View Scheme
参考文献
Sechi, Mario; Casu, Fabio; Campesi, Ilaria; Fiori, Stefano; Mariani, Alberto
Molecules, 2006 , vol. 11, # 12 p. 968 - 977
反应条件
in methanol Heating;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 35, # 8 p. 867 - 870
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.67 h / 0 °C 1.2: 45 percent / tetrahydrofuran / 3 h / -78 °C 2.1: 41 percent / hydrogen / platinum(IV) oxide / methanol / 3 h / 20 °C View Scheme
参考文献
Bernardes, Lilian Sibelle Campos; Kato, Massuo Jorge; Albuquerque, Sergio; Carvalho, Ivone
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7075 - 7082
反应条件
1.1: bromine / methanol / 5 - 40 °C / |Large scale 2.1: sulfuric acid / 6 h / 90 °C / |Inert atmosphere; |Large scale 3.1: ethanol / 4 h / |Reflux; |Large scale 4.1: sodium hydroxide; sodium tetrahydroborate / water / 1 h / 20 °C / |Large scale 5.1: formic acid / 1,4-dioxane; N,N-dimethyl-formamide / 10 h / |Reflux; |Large scale 6.1: potassium hexacyanoferrate(III); potassium carbonate / toluene / 1 h / 50 - 60 °C / |Large scale 7.1: toluene-4-sulfonic acid / toluene / |Reflux; |Large scale 8.1: lithium aluminium tetrahydride; hydrogen / tetrahydrofuran / 3 h / 60 - 65 °C / |Inert atmosphere; |Large scale 8.2: 0.25 h / |Large scale 8.3: 0.33 h / 60 °C / pH < 1 / |Large scale 9.1: triethylamine / ethanol / |Reflux; |Large scale View Scheme
参考文献
Kueenburg, Bernhard; Czollner, Laszlo; Frohlich, Johannes; Jordis, Ulrich
Organic Process Research and Development, 1999 , vol. 3, # 6 p. 425 - 431
反应条件
Yield given. Multistep reaction;
参考文献
Bubnov, Yu. N.; Gurskii, M. E.; Grandberg, A. I.; Pershin, D. G.
Tetrahedron, 1986 , vol. 42, # 4 p. 1079 - 1092
反应条件
1: trimethyl-sulfonium iodide With sodium hydride in tetrahydrofuran; dimethyl sulfoxide T=0°C; 0.166667 h; 2: 3,4-dimethoxy-benzaldehyde in tetrahydrofuran; dimethyl sulfoxide T=0 - 20°C; 1.5 h;
参考文献
WO2005/14530 A2, ;
Page/Page column 62-64 ;
反应条件
sodium hydroxide; tetra-(n-butyl)ammonium iodide in dichloromethane T=50°C;
参考文献
Synthetic Communications, , vol. 23, # 4 p. 473 - 486
反应条件
sodium hydroxide in dichloromethane; water T=50°C; Corey-Chaykovsky reaction; Phase-transfer catalyst;
参考文献
Russian Journal of Organic Chemistry, , vol. 44, # 12 p. 1776 - 1779
