3,4-二甲氧基苯甲醛合成路线 （共 996 条）
参考文献
Perkin; Ray; Robinson
Journal of the Chemical Society, 1926 , p. 943,946
Journal of the Chemical Society, 1927 , p. 2095,2098
反应条件
1.1: 100 percent / diethyl ether / 0 - 20 °C 2.1: s-BuLi; TMEDA / diethyl ether; tetrahydrofuran; hexane / -78 - -40 °C 2.2: 54 percent / trimethylaluminum / various solvents / 17 h / -40 °C 3.1: BH3*THF / tetrahydrofuran / 4 h / Heating 3.2: 83 percent / aqueous HCl / tetrahydrofuran / 0.02 h / Heating 4.1: 94 percent / methanol / 22 h / Heating 5.1: TFAA; TFA / toluene / 15 h / Heating 6.1: Raney nickel W2; hydrogen / ethanol / 22 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 23 p. 9486 - 9494
反应条件
1: pyridine; piperidine 2: thionyl chloride; N,N-dimethylformamide / 1,2-dichloro-ethane / 6 h / Heating View Scheme
参考文献
Vedernikov, Artem I.; Gromov, Sergey P.
Synthesis, 2001 , # 6 p. 889 - 892
反应条件
in water T=90°C; Wittig reaction; 1 h;
参考文献
El-Batta, Amer; Jiang, Changchun; Zhao, Wen; Anness, Robert; Cooksy, Andrew L.; Bergdahl, Mikael
Journal of Organic Chemistry, 2007 , vol. 72, # 14 p. 5244 - 5259
反应条件
trichlorosilane; triethylamine; triphenyl-phosphine oxide in dichloromethane T=-10 - 20°C;
参考文献
Smith, James M.; Greaney, Michael F.
Tetrahedron Letters, 2007 , vol. 48, # 49 p. 8687 - 8690
反应条件
in water T=90°C; Wittig reaction; 1 h;
参考文献
Dambacher, Jesse; Zhao, Wen; El-Batta, Amer; Anness, Robert; Jiang, Changchun; Bergdahl, Mikael
Tetrahedron Letters, 2005 , vol. 46, # 26 p. 4473 - 4477
参考文献
Moyna, Guillermo; Williams, Howard J.; Scott
Synthetic Communications, 1996 , vol. 26, # 11 p. 2235 - 2239
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1932 , vol. 270, p. 353,359
Full Text Show Details
Lewis; Ramage; Robinson
Journal of the Chemical Society, 1935 , p. 1412
反应条件
1: water; 1,4-dioxane / |Inert atmosphere 2: palladium diacetate; potassium phosphate; DMAC / |Inert atmosphere 3: ammonium acetate / |Inert atmosphere 4: lithium aluminium tetrahydride / diethyl ether / |Inert atmosphere 5: N,N,N',N,-tetramethylethylenediamine; lithium hexamethyldisilazane / benzene; hexane / 120 °C / |Inert atmosphere; |Sealed tube View Scheme
参考文献
Pouilhes, Annie; Baltaze, Jean-Pierre; Kouklovsky, Cyrille
Synlett, 2013 , vol. 24, # 14 art. no. ST-2013-D0541-L, p. 1805 - 1808
反应条件
1: 95 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 20 h / Ambient temperature 2: 95 percent / H2 / Pd/C 3: 93 percent / polyphosphoric acid / 4 h / 40 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 24 p. 4933 - 4938
