3,4-二甲氧基苯甲醛合成路线 （共 996 条）
参考文献
Dreyfus
Patent: DE193958 ;
反应条件
1: 95 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 20 h / Ambient temperature 2: 95 percent / H2 / Pd/C 3: 93 percent / polyphosphoric acid / 4 h / 40 °C 4: 3 percent / HBr View Scheme
参考文献
Beugelmans, Rene; Chastanet, Jacqueline; Ginsburg, Helene; Quintero-Cortes, Leticia; Roussi, Georges
Journal of Organic Chemistry, 1985 , vol. 50, # 24 p. 4933 - 4938
反应条件
1: 91 percent / aq. KOH / ethanol / 16 h / 20 °C 2: 76 percent / H2 / Lindlar catalyst / aq. methanol / 6 h / 2068.59 - 2585.74 Torr View Scheme
参考文献
ARIAD PHARMACEUTICALS, INCORPORATED; LI, Feng; WANG, Yihan
Patent: WO2012/103279 A2, 2012 ;
反应条件
1: 91 percent / aq. KOH / ethanol / 16 h / 20 °C 2: 76 percent / H2 / Lindlar catalyst / aq. methanol / 6 h / 2068.59 - 2585.74 Torr 3: 99 percent / K2CO3 / acetone / 20 h / 20 °C View Scheme
参考文献
ARIAD PHARMACEUTICALS, INCORPORATED; LI, Feng; WANG, Yihan
Patent: WO2012/103279 A2, 2012 ;
反应条件
piperidine in ethanol Knoevenagel condensation; Heating;
参考文献
Biersack; Zoldakova; Effenberger; Schobert
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 1972 - 1975
反应条件
potassium hydroxide in ethanol T=20°C; Condensation; 16 h;
参考文献
Keenan, Terence; Yaeger, David R.; Courage, Nancy L.; Rollins, Carl T.; Pavone, Mary Ellen; Rivera, Victor M.; Yang, Wu; Guo, Tao; Amara, Jane F.; Clackson, Tim; Gilman, Michael; Holt, Dennis A.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 8 p. 1309 - 1335
反应条件
hydrogenchloride; aqueous KOH in ethanol
参考文献
Ariad Pharmaceuticals, Inc.
Patent: US6150527 A1, 2000 ;
反应条件
1: 1.) n-BuLi / 1.) -70 deg C, 30 min, THF, 2.) -70 deg C -> room temp. 2: 100 percent / H2 / Pd-C (5percent) / acetic acid 3: H2 / PtO2 View Scheme
参考文献
Kozikowski, Alan P.; Ames, Anthony
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2548 - 2550
反应条件
sodium ethanolate in ethanol Ambient temperature;
参考文献
Majima, Tetsuro; Tojo, Sachiko; Ishida, Akito; Takamuku, Setsuo
Journal of Organic Chemistry, 1996 , vol. 61, # 22 p. 7793 - 7800
反应条件
sodium ethanolate T=80°C;
参考文献
Roberts, Jeffrey C.; Pincock, James A.
Journal of Organic Chemistry, 2004 , vol. 69, # 12 p. 4279 - 4282
