3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
in tetrahydrofuran; dimethyl sulfoxide 1.) 0-5 deg C, 15 min., 2.) r.t. 90 min.,;
参考文献
Alvarez; Granados; Lavilla; Salas
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 745 - 750
反应条件
1: 99 percent / KOH / ethanol / 3 h / 20 °C 2: 90 percent / BBr3 / CH2Cl2 / 0.5 h / 0 °C 3: 93 percent / dimethyl dioxirane / acetone; CH2Cl2 / 0.33 h / 0 - 20 °C 4: 41 percent / K2CO3 / acetone / 1 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 60, # 11 p. 2647 - 2655
反应条件
1: 40 percent / NaH, MeOH / toluene / 0 - 20 °C 2: 73 percent / hydrogen / 10 percent palladium on charcoal / acetic acid / 4 h / Ambient temperature 3: 82 percent / CaCl2, NaBH4 / ethanol / 0.25 h / Ambient temperature 4: 98 percent / pyridine / 0.33 h / 0 °C 5: 90 percent / LiBEt3 / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Schrecker
Journal of the American Chemical Society, 1957 , vol. 79, p. 3823,3825
反应条件
nitric acid 0 deg C -> room temperature, 1 h;
参考文献
Kumar, Sandeep; Wachtel, Ellen J.; Keinan, Ehud
Journal of Organic Chemistry, 1993 , vol. 58, # 15 p. 3821 - 3827
反应条件
unter Ausschluss von Tageslicht;
参考文献
Pschorr; Sumuleanu
Chemische Berichte, 1899 , vol. 32, p. 3407
参考文献
Salway
Journal of the Chemical Society, 1909 , vol. 95, p. 1165
Journal of the Chemical Society, 1911 , vol. 99, p. 267
反应条件
1: nitric acid / 5 - 10 °C 2: KOH-solution; KMnO4 3: hydrogen chloride View Scheme
参考文献
Pschorr; Sumuleanu
Chemische Berichte, 1899 , vol. 32, p. 3407
反应条件
1.1: bromine / methanol / 5 - 40 °C / |Large scale 2.1: sulfuric acid / 6 h / 90 °C / |Inert atmosphere; |Large scale 3.1: ethanol / 4 h / |Reflux; |Large scale 4.1: sodium hydroxide; sodium tetrahydroborate / water / 1 h / 20 °C / |Large scale 5.1: formic acid / 1,4-dioxane; N,N-dimethyl-formamide / 10 h / |Reflux; |Large scale 6.1: potassium hexacyanoferrate(III); potassium carbonate / toluene / 1 h / 50 - 60 °C / |Large scale 7.1: toluene-4-sulfonic acid / toluene / |Reflux; |Large scale 8.1: lithium aluminium tetrahydride; hydrogen / tetrahydrofuran / 3 h / 60 - 65 °C / |Inert atmosphere; |Large scale 8.2: 0.25 h / |Large scale 8.3: 0.33 h / 60 °C / pH < 1 / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 3, # 6 p. 425 - 431
反应条件
sulfuric acid; nitric acid T=-20°C; 168 h;
参考文献
Maya, Ana B. S.; Perez-Melero, Concepcion; Mateo, Carmen; Alonso, Dulce; Fernandez, Jose Luis; Gajate, Consuelo; Mollinedo, Faustino; Pelaez, Rafael; Caballero, Esther; Medarde, Manuel
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 556 - 568
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane; water T=20°C; Baeyer-Villiger oxidation; 15 h;
参考文献
Tummatorn, Jumreang; Khorphueng, Prapas; Petsom, Amorn; Muangsin, Nongnuch; Chaichit, Narongsak; Roengsumran, Sophon
Tetrahedron, 2007 , vol. 63, # 48 p. 11878 - 11885
