3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1.1: aq. NaOH 2.1: 84 percent / H2 / Pd/C / ethanol 3.1: LDA / tetrahydrofuran / 0.33 h / -78 °C 3.2: tetrahydrofuran / 3 h / -78 - 20 °C 4.1: 74 percent / 1,4-dicyanonaphthalene / acetonitrile; H2O / 4 h / Irradiation View Scheme
参考文献
Pandey, Ganesh; Karthikeyan; Murugan
Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2867 - 2872
反应条件
1: 35 g / bromine, iodine / acetic acid; CS2 / 48 h / Ambient temperature 2: sodium borohydride / ethanol / 1 h 3: 1) sodium hydride / 1) THF, room temp., 1 h; 2) room temp. 4: 1) LDA / 1) THF, -78 deg C, 10 min; 2) THF, -40 deg C, then 2 h to room temp. 5: 20 percent / acetic acid, hydrochloric acid / 1 h / Heating View Scheme
参考文献
Khanapure, Subhash P.; Biehl, Edward R.
Journal of Organic Chemistry, 1990 , vol. 55, # 5 p. 1471 - 1475
反应条件
1: (i) LDA, THF, (ii) /BRN= 473899/ 2: bis-(2-methoxy-ethyl) ether / 160 °C View Scheme
参考文献
Reutrakul,V. et al.
Chemistry Letters, 1979 , p. 209 - 212
反应条件
hydrogen bromide; bromine in acetic acid
参考文献
Chaplin, David A.; Fraser, Neil; Tiffin, Peter D.
Tetrahedron Letters, 1997 , vol. 38, # 45 p. 7931 - 7932
反应条件
zirconocene dichloride in tetrahydrofuran T=-78 - 20°C; 1.75 h;
参考文献
Roche Palo Alto LLC
Patent: US2007/49609 A1, 2007 ;
Location in patent: Page/Page column 86 ;
US 20070049609 A1
反应条件
1: diethyl ether / 2 h 2: potassium dichromate; aq. sulfuric acid / diethyl ether / 5 h / 25 °C View Scheme
参考文献
Hill, Kenneth A.; Peterson, Dorothy M.; Damodaran, Kalyani M.; Rao, P. Narasimha
Steroids, 1981 , vol. 37, # 3 p. 327 - 344
反应条件
silica-bonded N-propylpiperazine sulfamic acid in ethanol T=20°C; 0.0833333 h;
参考文献
Rahi, Tahere; Baghernejad, Mojtaba; Niknam, Khodabakhsh
Chinese Chemical Letters, 2012 , vol. 23, # 10 p. 1103 - 1106,4
反应条件
perchloric acid; sodium percarbonate; vanadium pentoxide 0.45 h; Cooling;
参考文献
Gopinath, Rangam; Barkakaty, Balaka; Talukdar, Bandana; Patel, Bhisma K.
Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2944 - 2947
反应条件
dihydrogen peroxide T=20°C; 8 h;
参考文献
Rafiee, Ezzat; Eavani, Sara
Journal of Molecular Catalysis A: Chemical, 2013 , vol. 373, p. 30 - 37
反应条件
copper quinolate; tetra-(n-butyl)ammonium iodide in water; dimethyl sulfoxide T=120°C; 24 h;
参考文献
Zhu, Yan; Yan, Hong; Lu, Linhua; Liu, Defu; Rong, Guangwei; Mao, Jincheng
Journal of Organic Chemistry, 2013 , vol. 78, # 19 p. 9898 - 9905
