3,4-二甲氧基苯甲醛 合成路线 （共 996 条）
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反应条件
482-20-2 (S)-9,11,12,13,13a,14-六氢-2,3,6,7-四甲氧基二苯并[f,h]吡咯并(1,2-b)异喹啉
反应条件
1: acetic anhydride; triethylamine / 20 h / Reflux
2: anhydrous iron chloride; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux
4: phosphorus tribromide / chloroform / 4 h / 20 °C / Inert atmosphere
5: potassium carbonate / N,N-dimethyl-formamide / 20 °C
6: acetic acid / methanol / 3 h / 45 °C
7: potassium hydroxide / 1,4-dioxane; methanol / 3 h
8: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Reflux
9: tin(IV) chloride / dichloromethane / 6 h / Reflux
10: sodium tetrahydroborate / ethanol / 6 h / 0 - 20 °C
11: triethylsilane; trifluoroacetic acid / dichloromethane / 0.5 h / Reflux
12: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / Reflux
View Scheme
参考文献
Wang, Kailiang; Su; Wang, Ziwen; Meng; Zheng; Yanna; Zhijin; Mi; Wang, Qingmin
反应条件
1.1: sodium tetrahydroborate; methanol / 0.33 h / 0 °C
2.1: acetic acid / 0.5 h / 0 °C
2.2: 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.25 h / -60 °C
3.2: 1 h
4.1: sodium amide / 2 h / 20 °C
5.1: borane-THF / tetrahydrofuran / 12 h / 20 °C
5.2: 1 h
6.1: triethylamine / dichloromethane / 20 °C
7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / |Reflux
8.1: ethanol / |Resolution of racemate
9.1: sodium hydroxide / ethyl acetate
10.1: potassium carbonate / acetone / 18 h / |Reflux
View Scheme
参考文献
LES LABORATOIRES SERVIER; CARRANZA, Maria Del Pilar; GARCIA ARANDA, Maria Isabel; GONZALEZ, José Lorenzo; SANCHEZ, Frédéric
反应条件
1: potassium permanganate; sodium hydrogencarbonate / water / 1 h / 90 °C
2: polyphosphoric acid / 2 h / 80 °C
3: sodium tetrahydroborate; trifluoroacetic acid / 0.5 h / 0 °C
View Scheme
参考文献
Jiang, Bo; Shi, Dayong; Cui, Yongchao; Guo, Shuju
反应条件
bismuth(III) chloride; hydrazine in water
T=20°C; 0.0166667 h; SonicationGreen chemistry;
参考文献
Khan, Khalid M.; Jamil, Waqas; Ambreen, Nida; Taha, Muhammad; Perveen, Shahnaz; Morales, Guillermo A.
反应条件
1: ethanol; aq. NaOH solution
2: selenium dioxide; amyl alcohol
3: aqueous hydriodic acid; acetic acid anhydride
View Scheme
参考文献
Oliverio; Bargellini
反应条件
1: 99 percent / KOH / ethanol / 3 h / 20 °C
2: 90 percent / BBr3 / CH2Cl2 / 0.5 h / 0 °C
3: 97 percent / K2CO3 / acetone / 2 h / Heating
4: 86 percent / dimethyl dioxirane / acetone; CH2Cl2 / 0.5 h / 0 - 20 °C
5: 96 percent / K2CO3 / acetone / 1 h / Heating
View Scheme
参考文献
Chu, Han-Wei; Wu, Huan-Ting; Lee, Yean-Jang
反应条件
sodium methylate in methanol; toluene
T=20°C; Darzens reaction; 0.75 h;
参考文献
Ottersbach, Philipp A.; Bolek, David; Lepicova, Eva; Nieger, Martin; Guetschow, Michael
反应条件
1: 99 percent / KOH / ethanol / 3 h / 20 °C
2: 90 percent / BBr3 / CH2Cl2 / 0.5 h / 0 °C
3: 97 percent / K2CO3 / acetone / 2 h / Heating
4: 86 percent / dimethyl dioxirane / acetone; CH2Cl2 / 0.5 h / 0 - 20 °C
View Scheme
参考文献
Chu, Han-Wei; Wu, Huan-Ting; Lee, Yean-Jang
反应条件
1: aq.-ethanolic NaOH
2: selenium dioxide; amyl alcohol
3: aqueous hydriodic acid; acetic acid anhydride
View Scheme
参考文献
Oliverio et al.
反应条件
1: sodium acetate / acetic anhydride / Heating
2: 3M aq. hydrochloric acid / Heating
3: acetyl chloride
4: 96 percent / 3 eq. NaBH4 / ethanol / 1 h / 20 °C
View Scheme
参考文献
Dalla, Vincent; Cotelle, Philippe; Catteau, Jean Pierre
