3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1: Ac2O, AcONa / 4 h / 100 °C
2: 1.) 1.0 N aq. NaOH, 2.) aq. HCl / 1.) steam bath, 2.) reflux, 4 h
View Scheme
参考文献
Baud, Matthias G. J.; Leiser, Thomas; Haus, Patricia; Samlal, Sharon; Wong, Ai Ching; Wood, Robert J.; Petrucci, Vanessa; Gunaratnam, Mekala; Hughes, Siobhan M.; Buluwela, Lakjaya; Turlais, Fabrice; Neidle, Stephen; Meyer-Almes, Franz-Josef; White, Andrew J. P.; Fuchter, Matthew J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1731 - 1750
反应条件
1: in tetrahydrofuran
T=0°C; Green chemistry;
2: With [bis(acetoxy)iodo]benzene
T=0 - 20°C; Green chemistry;
参考文献
Sagara, Prateep Singh; Chebolu, Rajesh; Bahuguna, Ashish; Ravikumar
RSC Advances, 2014 , vol. 4, # 29 p. 15011 - 15013
反应条件
1: 74 percent / magnesium / tetrahydrofuran / 2 h / 20 °C
2: 82 percent / CrO3; aq. H2SO4 / acetone
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 95 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 20 h / Ambient temperature
2: 95 percent / H2 / Pd/C
3: 93 percent / polyphosphoric acid / 4 h / 40 °C
4: 68 percent / NH3(liq.), t-C4H9OK, air / Irradiation
5: 68 percent / 30percent Pd/C / 4 h / 250 °C
View Scheme
参考文献
Beugelmans, Rene; Chastanet, Jacqueline; Ginsburg, Helene; Quintero-Cortes, Leticia; Roussi, Georges
Journal of Organic Chemistry, 1985 , vol. 50, # 24 p. 4933 - 4938
反应条件
1: AcOH / ethanol / 20 h / Heating
2: NaBH4 / methanol / 1 h / Ambient temperature
3: 98 percent / Ac2O / 1 h / 70 °C
4: 96 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature
5: 97 percent / TFAA / benzene / 20 h / Ambient temperature
6: 74 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
7: 87 percent / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Takano, Seiichi; Iida, Hirokazu; Inomata, Kohei; Ogasawara, Kunio
Heterocycles, 1993 , vol. 35, # 1 p. 47 - 52
反应条件
1.1: acetic acid; ammonium acetate / 20 - 120 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / |Reflux
3.1: toluene / 20 h / 20 °C / |Reflux
4.1: trichlorophosphate / toluene / 4.5 h / 20 °C / |Reflux
4.2: 16 h / 0 - 20 °C
View Scheme
参考文献
Crestey, Francois; Jensen, Anders A.; Borch, Morten; Andreasen, Jesper Tobias; Andersen, Jacob; Balle, Thomas; Kristensen, Jesper Langgaard
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9673 - 9682
反应条件
1: sodium
2: palladium; acetic acid / Hydrogenation
3: aqueous ammonia
View Scheme
参考文献
Jirkovsky,I.; Protiva,M.
Collection of Czechoslovak Chemical Communications, 1967 , vol. 32, # 3 p. 1197 - 1209
反应条件
1: AcOH / ethanol / 20 h / Heating
2: NaBH4 / methanol / 1 h / Ambient temperature
3: 96 percent / pyridine / 16 h / Ambient temperature
4: 93 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature
View Scheme
参考文献
Takano, Seiichi; Iida, Hirokazu; Inomata, Kohei; Ogasawara, Kunio
Heterocycles, 1993 , vol. 35, # 1 p. 47 - 52
反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / -78 °C / |Inert atmosphere
1.2: -78 °C / |Inert atmosphere
2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 20 °C / |Inert atmosphere
3.1: zinc(II) iodide / dichloromethane; toluene / 72 h / 40 °C / |Inert atmosphere
3.2: 16 h / 40 °C / |Inert atmosphere
4.1: sulfuric acid / 1 h / 60 °C / |Inert atmosphere
View Scheme
参考文献
Puenner, Florian; Schieven, Justin; Hilt, Gerhard
Organic Letters, 2013 , vol. 15, # 18 p. 4888 - 4891
反应条件
1: 66 percent / sodium ethoxide
2: 50 percent / H2 / 10percent palladium on carbon / ethanol
View Scheme
参考文献
Crombie, Leslie; Jamieson, Sally V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1467 - 1476
