3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1: 60 percent / Perkin reaction
2: 57 percent / modified Curtius reaction
3: toluene / Heating
4: diphenyl ether / Heating
5: POCl3
View Scheme
参考文献
Tamao, K.; Kodama, S.; Nakajima, I.; Kumada, M.; Minato, A.; Suzuki, K.
Tetrahedron, 1982 , vol. 38, # 22 p. 3347 - 3354
反应条件
1: 99 percent / KOH / ethanol / 3 h / 20 °C
2: 90 percent / BBr3 / CH2Cl2 / 0.5 h / 0 °C
3: 65 percent / dimethyl dioxirane / acetone; CH2Cl2 / 1 h / 0 - 20 °C
4: 95 percent / K2CO3 / acetone / 6 h / Heating
5: 71 percent / I2; pyridine / 8 h / Heating
6: 94 percent / BBr3 / CH2Cl2 / 0.5 h / 0 °C
View Scheme
参考文献
Chu, Han-Wei; Wu, Huan-Ting; Lee, Yean-Jang
Tetrahedron, 2004 , vol. 60, # 11 p. 2647 - 2655
反应条件
1: 99 percent / KOH / ethanol / 3 h / 20 °C
2: 90 percent / BBr3 / CH2Cl2 / 0.5 h / 0 °C
View Scheme
参考文献
Chu, Han-Wei; Wu, Huan-Ting; Lee, Yean-Jang
Tetrahedron, 2004 , vol. 60, # 11 p. 2647 - 2655
反应条件
potassium cyanide in N,N-dimethyl-formamide
T=80°C; 1 h;
参考文献
Miyashita, Akira; Suzuki, Yumiko; Ohta, Kiyono; Iwamoto, Ken-Ichi; Higashino, Takeo
Heterocycles, 1998 , vol. 47, # 1 p. 407 - 414
反应条件
in tetrahydrofuran
T=20°C; 2 h;
参考文献
Chassaing, Stefan; Kueny-Stotz, Marie; Isorez, Geraldine; Brouillard, Raymond
European Journal of Organic Chemistry, 2007 , # 15 p. 2438 - 2448
反应条件
ethylenediamine in dimethyl sulfoxide
T=20°C; 1 h;
参考文献
Bernardes, Lilian Sibelle Campos; Kato, Massuo Jorge; Albuquerque, Sergio; Carvalho, Ivone
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7075 - 7082
参考文献
Clapperton; MacGregor
Journal of the American Chemical Society, 1949 , vol. 71, p. 3234
反应条件
ammonia; sodium
2) ether, 4 h; Yield given. Multistep reaction;
参考文献
Ranu, Brindaban C.; Bhar, Sanjay; Chakraborti, Ratna
Journal of Organic Chemistry, 1992 , vol. 57, # 28 p. 7349 - 7352
反应条件
sodium hydroxide; hydroxylammonium sulfate in methanol; water
参考文献
INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES
Patent: EP2511283 A1, 2012 ;
反应条件
in methanol; chloroform
T=20°C; 0.5 h;
参考文献
Khalaji; Foroghnia; Fejfarova; Dusek
Journal of Structural Chemistry, 2013 , vol. 54, # 4 p. 774 - 778
Zh. Strukt. Kim., 2013 , vol. 54, # 4 p. 728 - 732,5
