3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
phenyllithium
1.) THF, 15 min, 2.) THF, a.) RT, 2 h, b.) 3 h, reflux; Yield given. Multistep reaction;
参考文献
Tuntiwachwuttikul, Pittaya; Limchawfar, Burin; Reutrakul, Vichai; Pancharoen, Orasa; Kusamran, Kosan; Byrne, Lindsay T.
Australian Journal of Chemistry, 1980 , vol. 33, # 4 p. 913 - 916
反应条件
1: potassium carbonate / methanol / |Reflux
2: potassium carbonate; palladium diacetate; copper(l) iodide / N,N-dimethyl-formamide / 150 °C / |Microwave irradiation
View Scheme
参考文献
Mahuteau-Betzer, Florence; Piguel, Sandrine
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3188 - 3193
反应条件
1: aq. NaOH / methanol / 0.5 h / 0 - 5 °C
2: silica gel, NaBH4 / CHCl3; propan-2-ol / 0.25 h / 25 °C
View Scheme
参考文献
USV Pharmaceutical Corporation
Patent: US4701461 A1, 1987 ;
Title/Abstract Full Text Show Details
USV Pharmaceutical Corp.
Patent: US4569941 A1, 1986 ;
反应条件
sodium acetate; propionic acid anhydride
T=175°C;
参考文献
Garnelis, Thomas; Athanassopoulos, Constantinos M.; Papaioannou, Dionissios; Eggleston, Ian M.; Fairlamb, Alan H.
Chemistry Letters, 2005 , vol. 34, # 2 p. 264 - 265
反应条件
piperidine; pyridine
参考文献
Gensler; Berman
Journal of the American Chemical Society, 1958 , vol. 80, p. 4949,4952
反应条件
zinc; benzene
Erwaermen der Reaktionsloesung mit Phosphoroxychlorid und Behandeln des Reaktionsprodukts mit methanol. Kalilauge;
参考文献
Ide; Buck
Journal of the American Chemical Society, 1940 , vol. 62, p. 425,427
反应条件
1: 3,4-dimethoxy-benzaldehyde With Br3COOEt; dibenzoyl peroxide in chlorobenzene
T=110°C; 24 h;
2: diethylamine With triethylamine in chlorobenzene
T=20°C;
参考文献
Kang, Dong Ho; Joo, Tae Young; Chavasiri, Warinthorn; Jang, Doo Ok
Tetrahedron Letters, 2007 , vol. 48, # 2 p. 285 - 287
反应条件
1: H2O; methanol / 4 h / Ambient temperature
2: 64 percent / 50percent aq. NaOH, benzyltriethylammonium chloride, O2 / dimethylsulfoxide / 4 h
View Scheme
参考文献
Yuste, Francisco; Origel, Alfredo E.; Brena, Leonardo J.
Synthesis, 1983 , # 2 p. 109 - 110
反应条件
1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
2: p-TosOH / xylene / 5.5 h / Heating
3: tetra-n-butyl ammonium hydrogen sulfate, NaOH / CH2Cl2; H2O / 16 h / Ambient temperature
4: LiBu / tetrahydrofuran; hexane / 0.33 h / -78 °C
5: p-TosOH / 1 h / 190 °C
6: 480 mg / BBr3 / CH2Cl2 / 1) -78 deg C, 2) -78 deg C to r.t. overnight
View Scheme
参考文献
Hill, Kenneth A.; Peterson, Dorothy M.; Damodaran, Kalyani M.; Rao, P. Narasimha
Steroids, 1981 , vol. 37, # 3 p. 327 - 344
反应条件
boron trifluoride diethyl etherate in dichloromethane
70 h; Ambient temperature;
参考文献
Couquelet; Taoufik; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 301 - 305
