3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
sodium hydroxide; ammonium chloride in tetrahydrofuran; methanol; water
参考文献
Terumo Corporation
Patent: US4673684 A1, 1987 ;
反应条件
1: 1.) N,N,N'-trimethylethylenediamine, n-BuLi, 2.) hexachloroethane / 1.) THF, from -70 deg C to -30 deg C, 8 h, 2.) THF, RT, 3 h
2: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature
3: 84 percent / SOCl2 / 24 h / Heating
4: 67 percent / 18-crown-6 / acetonitrile / 168 h / Heating
View Scheme
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
反应条件
zinc(II) chloride
T=150°C; Inert atmosphere;
参考文献
Eroes, Gabor; Nagy, Krisztina; Mehdi, Hasan; Papai, Imre; Nagy, Peter; Kiraly, Peter; Tarkanyi, Gabor; Soos, Tibor
Chemistry - A European Journal, 2012 , vol. 18, # 2 p. 574 - 585
反应条件
diiodo monosilane in chloroform-d1
T=22°C; 0.5 h;
参考文献
Keinan, E.; Perez, D.; Sahai, M.; Shvily, R.
Journal of Organic Chemistry, 1990 , vol. 55, # 9 p. 2927 - 2938
反应条件
Horner-Emmons olefination reaction;
参考文献
Demina; Varfolomeev; Lukin, A. Yu; Laptev; Shvets; Khodonov; Khitrina; Gromov; Vedernikov; Barachevsky; Strokach, Yu P.; Alfimov; Lugtenburg
Molecular Crystals and Liquid Crystals, 2005 , vol. 431, p. 209/[509]-214/[514]
反应条件
sodium hydroxide in ethanol; water
Ambient temperature;
参考文献
Yakovenko, V. I.; Oganesyan, E. T.; Dorofeenko, G. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1981 , vol. 17, # 2 p. 115 - 118
Khimiya Geterotsiklicheskikh Soedinenii, 1981 , vol. 17, # 2 p. 170 - 173
反应条件
1: CuCl2·2H2O; C15H28N2; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / -20 °C
2: palladium 10 on activated carbon; hydrogen / methanol / 20 °C / 760.05 Torr
3: sodium hydroxide / water / pH 10
View Scheme
参考文献
Zhou, Yirong; Dong, Junfang; Zhang, Fanglin; Gong, Yuefa
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 588 - 600
反应条件
piperidine; acetic acid in toluene
6 h; Inert atmosphereReflux;
参考文献
Osman, Noha A.; Mahmoud, Amr H.; Allar, Marco; Niess, Raimund; Abouzid, Khaled A.; Marzo, Vincenzo Di; Abadi, Ashraf H.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 24 p. 8463 - 8477
反应条件
hydrogenchloride in ethanol
Heating;
参考文献
Kozlov; Basalaeva; Firgang; Shashkov
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 4 p. 518 - 524
反应条件
hydrogenchloride in ethanol
Heating;
参考文献
Kozlov; Basalaeva; Firgang; Shashkov
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 4 p. 518 - 524
