3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1: With potassium carbonate in ethanol
T=45°C; 18 h;
2: With hydrogenchloride in ethanol; water
T=20°C; pH=1;
参考文献
Hossain, Md. Imran; Shaban, Elkhabiry; Ikemi, Taku; Peng, Wei; Kawafuchi, Hiroyuki; Inokuchi, Tsutomu
Bulletin of the Chemical Society of Japan, 2013 , vol. 86, # 7 p. 870 - 879
反应条件
sodium hydrogensulfite
T=40°C; 3 h;
参考文献
Goeker, Hakan; Oezden, Seckin; Yildiz, Sulhiye; Boykin, David W.
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 10 p. 1062 - 1069
反应条件
phenyllithium
1.) THF, room temperature, 1 h; 2.) THF, 2 h, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Tuntiwachwuttikul, Pittaya; Pancharoen, Orasa; Jaipetch, Thaworn; Reutrakul, Vichai
Phytochemistry (Elsevier), 1981 , vol. 20, # 5 p. 1164 - 1165
反应条件
1) Et2O, reflux, 30 min, 2) 170 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Schmidt, Arthur H.; Kircher, Gunnar; Spring, Mathias; Hendriok, Markus W.; Kuenz, Christian
Advanced Synthesis and Catalysis, 1997 , vol. 339, # 6 p. 564 - 574
反应条件
sodium in ethanol
12 h; Ambient temperature;
参考文献
Yokoe; Higuchi; Shirataki; Komatsu
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 9 p. 2670 - 2674
反应条件
in acetic acid
T=130 - 140°C; 0.5 h;
参考文献
Oganesyan, E.T.; Saraf, A.S.; Ivchenko, A.V.
Pharmaceutical Chemistry Journal, 1993 , vol. 27, # 1 p. 52 - 54
Khimiko-Farmatsevticheskii Zhurnal, 1993 , vol. 27, # 1 p. 41 - 43
参考文献
Rai, Mangat; Kaur, Baljit; Dhir, B. S.
Journal of the Indian Chemical Society, 1982 , vol. 59, # 3 p. 416 - 417
反应条件
1.1: 60 percent / Br2 / acetic acid / 20 °C
2.1: 87 percent / NaBH4 / tetrahydrofuran / 20 °C
3.1: 78 percent / NaH; BuLi / tetrahydrofuran / -78 °C
4.1: 75 percent / PCC/Al2O3 / CH2Cl2 / 20 °C
5.1: NaOEt / tetrahydrofuran; ethanol / 0 °C
6.1: NaH; LiBH4 / dioxane / 28 h / Heating
6.2: 67 percent / aq. HCl
View Scheme
参考文献
Harrowven, David C; Bradley, Mark; Lois Castro, J; Flanagan, Stuart R
Tetrahedron Letters, 2001 , vol. 42, # 39 p. 6973 - 6975
反应条件
acetic acid
3 - 5 h;
参考文献
Elmuradov; Abdurazakov; Shakhidoyatov
Chemistry of Natural Compounds, 2008 , vol. 44, # 4 p. 475 - 479
参考文献
Rai, Mangat; Kaur, Baljit; Dhir, B. S.
Journal of the Indian Chemical Society, 1982 , vol. 59, # 3 p. 416 - 417
