3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
2: p-TosOH / xylene / 5.5 h / Heating
View Scheme
参考文献
Hill, Kenneth A.; Peterson, Dorothy M.; Damodaran, Kalyani M.; Rao, P. Narasimha
Steroids, 1981 , vol. 37, # 3 p. 327 - 344
反应条件
1.1: potassium hydroxide / ethanol / 12 h / 0 - 20 °C
1.2: pH 3 - 4 / |Cooling with ice
2.1: Aspergillus niger LSPN001 / ethanol / 120 h / 20 °C / |Enzymatic reaction
View Scheme
参考文献
Alarcon, Julio; Alderete, Joel; Escobar, Carlos; Araya, Ramiro; Cespedes, Carlos L.
Biocatalysis and Biotransformation, 2013 , vol. 31, # 4 p. 160 - 167
反应条件
1: NaOEt / ethanol
2: 6.0 g / 30 percent H2O2; NaOEt / ethanol / 0 - 20 °C
View Scheme
参考文献
Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba
Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210
反应条件
1.1: sodium ethanolate / ethanol / 1 h / 20 °C
1.2: 20 °C
1.3: pH 1
2.1: dihydrogen peroxide; sodium hydroxide / methanol; water / 0 - 20 °C
View Scheme
参考文献
Britton, Robert G.; Horner-Glister, Emma; Pomenya, Odette A.; Smith, Ewan E.; Denton, Roanne; Jenkins, Paul R.; Steward, William P.; Brown, Karen; Gescher, Andreas; Sale, Stewart
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 952 - 958
参考文献
Gowan et al.
Journal of the Chemical Society, 1955 , p. 862,866
反应条件
1: With methanol; sodium
2: succinic acid dimethyl ester in methanol
T=20°C; 1 h;
3: 3,4-dimethoxy-benzaldehyde With citric acid
more than 3 stages;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/192729 A1, 2004 ;
Location in patent: Page 28 ;
反应条件
tert-butyl alcohol in tert-butyl alcohol
T=40°C; 0.5 h;
参考文献
Moritani; Fukushima; Miyagishima; Ohmizu; Iwasaki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 8 p. 2281 - 2286
反应条件
sodium hydroxide in methanol
10 h; Ambient temperature;
参考文献
Wattanasin, Sompong; Murphy, William S.
Synthesis, 1980 , # 8 p. 647 - 650
反应条件
1: 92 percent / HCl gas / dioxane / 1 h / Heating
2: 48 percent / chromium trioxide, 35percent H2SO4 / acetone; H2O / 2 h / Ambient temperature
3: 60 percent / hydrazin hydrate 98percent / ethanol / 1 h / Heating
4: 64 percent / 3 h / Heating
View Scheme
参考文献
Gatta; Piazza; Del Giudice; Massotti
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 12 p. 942 - 955
反应条件
zinc(II) chloride
1. acetic anhydride, room temperature, 48 h; 2. H2O, benzene, 1 h; Yield given. Multistep reaction;
参考文献
Arnold, Zdenek; Kral, Vladimir; Dvorak, Dalimil
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 11 p. 2602 - 2612
