3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1: sodium tetrahydroborate / isopropyl alcohol / 20 °C
2: phosphorus tribromide / dichloromethane / 20 °C
3: sodium azide / N,N-dimethyl-formamide / 20 °C
View Scheme
参考文献
Su, Na; Wang, Zhen-Jun; Wang, Li-Zhong; Zhang, Xiao; Dong, Wei-Li; Wang, Hong-Xue; Li, Zheng-Ming; Zhao, Wei-Guang
Chemical Biology and Drug Design, 2011 , vol. 78, # 1 p. 101 - 111
反应条件
1: 91 percent / bromine / methanol / 1 h / cooling
2: 85 percent / sulfuric acid / 6 h / 90 °C
3: 90 percent / potassium carbonate / acetone / 4 h / Heating
4: 85 percent / ammonium acetate; acetic acid / 4 h / 100 °C
5: 80 percent / sodium borohydride / ethanol / 2 h / 0 °C
View Scheme
参考文献
Chandrasekhar; Reddy, N. Ramakrishna; Rao, Y. Srinivasa
Tetrahedron, 2006 , vol. 62, # 51 p. 12098 - 12107
反应条件
1: boric acid anhydride
2: H2 / Pd/C / methanol
View Scheme
参考文献
Pfeiffer, Erika; Hoehle, Simone I.; Walch, Stephan G.; Riess, Alexander; Solyom, Aniko M.; Metzler, Manfred
Journal of Agricultural and Food Chemistry, 2007 , vol. 55, # 2 p. 538 - 544
反应条件
1: pyridine
2: 82 percent
3: 81 percent / LiAlH4 / diethyl ether / 4 h / 0 °C
4: 72 percent / SOCl2, pyridine / CH2Cl2 / 1 h / Heating
View Scheme
参考文献
Drewes, Siegfried E.; Hall, Alida J.; Learmonth, Robin A.; Upfold, Ursula J.
Phytochemistry (Elsevier), 1984 , vol. 23, # 6 p. 1313 - 1316
反应条件
sodium hydroxide in ethanol; water
T=20°C; Claisen Schmidt condensation; 0.666667 h;
参考文献
Majeed, Jaseela; Shaharyar
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 6 p. 819 - 826
反应条件
sodium hydroxide; ethanol
unter Luftzutritt;
参考文献
Marathe
Journal of the University of Poona, Science and Technology, 1958 , # 14 p. 63,66
参考文献
Gowan et al.
Journal of the Chemical Society, 1955 , p. 862,866
反应条件
1: 1.) N,N,N'-trimethylethylenediamine, n-BuLi, 2.) hexachloroethane / 1.) THF, from -70 deg C to -30 deg C, 8 h, 2.) THF, RT, 3 h
2: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
反应条件
zinc diiodide in dichloromethane; water
参考文献
Nikken Chemicals Co., Ltd.
Patent: US6265402 B1, 2001 ;
反应条件
1: ZnI2 / CH2Cl2 / 2 h
2: lithium aluminum hydride / tetrahydrofuran / 1.5 h / 50 °C
View Scheme
参考文献
Blair, Adele; Stevenson, Louise; Sutherland, Andrew
Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4084 - 4086
