3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
sodium methylate
Man saeuert das Reaktionsprodukt mit Essigsaeure an und reduziert mit Natriumamalgam;
参考文献
Poos,G.I. et al.
Journal of Medicinal Chemistry, 1963 , vol. 6, p. 266 - 272
反应条件
1: 68 percent / acetic anhydride / Heating
2: 84 percent / Na2CO3
3: H2 / <Rh(R-PROPHOS)(NBD)>PF6 / tetrahydrofuran / 17 h
4: 94.8 percent / conc. HCl / H2O / 20 h / Heating
View Scheme
参考文献
O'Reilly; Derwin; Lin
Synthesis, 1990 , # 7 p. 550 - 556
反应条件
2: 75 percent / Pd/C / methanol / 8 h / 2427.2 Torr
3: 80 percent / conc. H2SO4 / methanol / 6 h / Heating; reflux
4: 80 percent / LAH / diethyl ether / 7 h / Heating
View Scheme
参考文献
Neelima; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 3 p. 209 - 215
反应条件
1: 1.) N,N,N'-trimethylethylenediamine, n-BuLi, 2.) hexachloroethane / 1.) THF, from -70 deg C to -30 deg C, 8 h, 2.) THF, RT, 3 h
2: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature
3: 84 percent / SOCl2 / 24 h / Heating
View Scheme
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
反应条件
1: aq.-ethanolic NaOH-solution
2: selenium dioxide; amyl alcohol
View Scheme
参考文献
Bargellini; Oliverio
Chemische Berichte, 1942 , vol. 75, p. 2083,2086
反应条件
potassium hydroxide
zuletzt bei 50-60grad;
参考文献
Freudenberg; Orthner; Fikentscher
Justus Liebigs Annalen der Chemie, 1924 , vol. 436, p. 296
反应条件
man behandelt das Kondensationsprodukt zunaechst mit Brom und dann mit methylalkoholischem Kali und verseift das so erhaltene Dimethylacetal des ω-Nitro-acetoveratrons mit Saeuren;
参考文献
Seter (Strumza),J.
Israel Journal of Chemistry, 1966 , vol. 4, p. 7 - 22
反应条件
1: sodium hydroxide / water; methanol / 4 h / 20 °C
2: sodium periodate / dimethyl sulfoxide / 72 h / 100 °C / |Inert atmosphere
3: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Ribeiro, Daniela; Freitas, Marisa; Tome, Sara M.; Silva, Artur M. S.; Porto, Graca; Fernandes, Eduarda
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 280 - 292
反应条件
1: 89 percent / ammonium acetate / benzene / 6 h / Heating
2: 44 percent / methanol
3: 78 percent / H2 / Raney Ni / ethanol / 2844.3 Torr
View Scheme
参考文献
Walker; Boots; Stubbins; Rogers; Davis
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 174 - 181
反应条件
1: methanol; H2O / Ambient temperature
2: 84 percent / NaH / dimethylformamide / Ambient temperature
View Scheme
参考文献
Badia, D.; Dominguez, E.; Galarza, J.; Lete, E.; Marigorta, E. Martinez de; Villa, M. J.
Bulletin des Societes Chimiques Belges, 1989 , vol. 98, # 1 p. 77 - 82
