3,4-二甲氧基苯甲醛合成路线 （共 996 条）
参考文献
The Upjohn Company
Patent: US3975431 A1, 1976 ;
反应条件
montmorillonite K10 in methanol
T=40°C; 18 h; Inert atmosphere;
参考文献
Laurent, Mathieu Y.; Stocker, Vivien; Temgoua, Valery Momo; Dujardin, Gilles; Dhal, Robert
Tetrahedron Letters, 2011 , vol. 52, # 14 p. 1608 - 1611
反应条件
1: BF3-Et2O / CHCl3
2: Tl(NO3)3, iPr2NH / diethyl ether
View Scheme
参考文献
Fujita,E. et al.
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 12 p. 3743 - 3751
反应条件
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.5 h / 0 °C
1.2: 20 °C
2.1: palladium 10 on activated carbon; hydrogen / ethanol / 5 h / 20 °C
3.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
View Scheme
参考文献
Al-Horani, Rami A.; Desai, Umesh R.
Tetrahedron, 2012 , vol. 68, # 8 p. 2027 - 2040
反应条件
1: NaBH4 / methanol
2: pyridine / benzene / Ambient temperature
3: 28 percent Chromat. / methanol / Irradiation
View Scheme
参考文献
Erdtman
Justus Liebigs Annalen der Chemie, 1933 , vol. 505, p. 195,201
反应条件
in ethanol; water
T=80°C; Knoevenagel condensation;
参考文献
Luo, Youfu; Ma, Liang; Zheng, Hao; Chen, Lijuan; Li, Rui; He, Chunmei; Yang, Shengyong; Ye, Xia; Chen, Zhizhi; Li, Zicheng; Gao, Yan; Han, Jing; He, Gu; Yang, Li; Wei, Yuquan
Journal of Medicinal Chemistry, 2010 , vol. 53, # 1 p. 273 - 281
反应条件
1: sodium acetate / water
2: lithium perchlorate / acetonitrile / 4 h / 20 °C / |Electrolysis
View Scheme
参考文献
Kumar, Sanjeev; Pandey
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 2 p. 252 - 258
反应条件
1: sodium hydroxide
2: methanol / |Acidic conditions
View Scheme
参考文献
Ansari, Farzana Latif; Kalsoom, Saima; Zaheer-Ul-Haq; Ali, Zahra; Jabeen, Farukh
Medicinal Chemistry Research, 2012 , vol. 21, # 9 p. 2329 - 2339
反应条件
1: NaOEt / ethanol
2: 6.0 g / 30 percent H2O2; NaOEt / ethanol / 0 - 20 °C
3: 44 percent / 57 percent aq. HI / Heating
View Scheme
参考文献
Sobottka; Werner; Blaschke; Kiefer; Nowe; Dannhardt; Schapoval; Schenkel; Scriba
Archiv der Pharmazie, 2000 , vol. 333, # 7 p. 205 - 210
反应条件
1.1: 80 percent / ammonium acetate; acetic acid / 1.5 h / Heating
2.1: LiAlH4 / tetrahydrofuran / 3 h / Heating
3.1: HOBt; DCC / dimethylformamide / 12 h
3.2: 95 percent / dimethylformamide / 12 h
4.1: 85 percent / POCl3 / toluene / 3 h / Heating
View Scheme
参考文献
Sawant, Devesh; Kumar, Rishi; Maulik, Prakas R.; Kundu, Bijoy
Organic Letters, 2006 , vol. 8, # 8 p. 1525 - 1528
