3,4-二甲氧基苯甲醛合成路线 （共 996 条）
参考文献
Napoly, Francois; Jean-Gerard, Ludivine; Goux-Henry, Catherine; Draye, Micheline; Andrioletti, Bruno
European Journal of Organic Chemistry, 2014 , vol. 2014, # 4 p. 781 - 787
反应条件
hydrogenchloride in ethanol
Heating;
参考文献
Bouvier,P. et al.
European Journal of Medicinal Chemistry, 1976 , vol. 11, p. 271 - 278
反应条件
iodine; silver sulphate in ethanol
T=20°C; 3 h; Inert atmosphere;
参考文献
FIBROTECH THERAPEUTICS PTY LTD; WILLIAMS, Spencer John; ZAMMIT, Steven; KELLY, Darren James
Patent: WO2011/47432 A1, 2011 ;
Location in patent: Page/Page column 92-93 ;
反应条件
potassium hydroxide in methanol; water
T=20°C; Claisen-Schmidt Condensation;
参考文献
Prasad, Y.Rajendra; Rani, V. Jhansi; Rao, A. Srinivasa
Asian Journal of Chemistry, 2013 , vol. 25, # 1 p. 52 - 58
反应条件
sodium formate; acetic acid
参考文献
Kaye; Kogon
Recueil des Travaux Chimiques des Pays-Bas, 1952 , vol. 71, p. 309,314
反应条件
ammonium acetate in ethanol; water
T=45°C;
参考文献
Xie, Yuli; Raffo, Anthony; Ichise, Masanori; Deng, Shixian; Harris, Paul E.; Landry, Donald W.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 5111 - 5114
反应条件
1.1: triphenylphosphine / CH2Cl2 / 0.5 h / 0 °C
1.2: 88 percent / CH2Cl2 / 1 h / 0 °C
2.1: n-BuLi / hexane / 1.5 h / -78 - 0 °C
2.2: 93 percent / hexane / 1.17 h / -78 - 0 °C
View Scheme
参考文献
O'Malley, Steven J.; Tan, Kian L.; Watzke, Anja; Bergman, Robert G.; Ellman, Jonathan A.
Journal of the American Chemical Society, 2005 , vol. 127, # 39 p. 13496 - 13497
反应条件
1: carbon tetrabromide; 3,4-dimethoxy-benzaldehyde With triphenylphosphine in dichloromethane
T=0 - 20°C; Corey-Fuchs method; 3 h; Inert atmosphere;
2: With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 20°C; Corey-Fuchs method; 1 h; Inert atmosphere;
3: methyl chloroformate in tetrahydrofuran; hexane
T=-78 - 20°C; Corey-Fuchs method; 1 h; Inert atmosphere;
参考文献
Hajbi, Youssef; Neagoie, Cleopatra; Biannic, Berenger; Chilloux, Aurelie; Vedrenne, Emeline; Baldeyrou, Brigitte; Bailly, Christian; Merour, Jean-Yves; Rosca, Sorin; Routier, Sylvain; Lansiaux, Amelie
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 5428 - 5437
反应条件
1.1: potassium hydroxide / ethanol / 12 h / 0 - 20 °C
1.2: pH 3 - 4 / |Cooling with ice
2.1: Aspergillus niger LSPN001 / ethanol / 120 h / 20 °C / |Enzymatic reaction
View Scheme
参考文献
Alarcon, Julio; Alderete, Joel; Escobar, Carlos; Araya, Ramiro; Cespedes, Carlos L.
Biocatalysis and Biotransformation, 2013 , vol. 31, # 4 p. 160 - 167
反应条件
1.1: boron trifluoride diethyl etherate / dichloromethane / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C
2.2: 1 h / -78 °C
3.1: N-chloro-succinimide; silver nitrate / acetonitrile; water / 20 °C
View Scheme
参考文献
Kothapalli, Raveendra Babu; Niddana, Ramana; Balamurugan, Rengarajan
Organic Letters, 2014 , vol. 16, # 5 p. 1278 - 1281
