3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1: NH4OAc / acetic acid / 3 h / Heating
2: Fe, FeCl3, aq. HCl / 1 h / Heating
3: (i) NaOiPr, iPrOH, (ii) /BRN= 969135/
View Scheme
参考文献
Binovic,K.; Vrancea,S.
Chimica Therapeutica, 1968 , vol. 3, p. 313 - 320
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C / |Inert atmosphere
1.2: 4.33 h / -78 - 20 °C / |Inert atmosphere
2.1: dipyridinium dichromate / dichloromethane / 24 h / 0 - 15 °C / |Inert atmosphere
View Scheme
参考文献
Peng, Yu; Luo, Zhen-Biao; Zhang, Jian-Jian; Luo, Long; Wang, Ya-Wen
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 43 p. 7574 - 7586
反应条件
bis(acetylacetonate)nickel(II); potassium carbonate in toluene
T=180°C; 0.166667 h; Microwave irradiation;
参考文献
Chen, Wen; Baghbanzadeh, Mostafa; Kappe, C. Oliver
Tetrahedron Letters, 2011 , vol. 52, # 14 p. 1677 - 1679
反应条件
1: bromobenzene With iodine; magnesium in diethyl ether
T=0°C; 0.166667 h;
2: 3,4-dimethoxy-benzaldehyde in diethyl ether
12 h;
参考文献
Zhang, Wei; Zhang, Wenxue; Dai, Yisi; Zhu, Haizhen
Tetrahedron Letters, 2013 , vol. 54, # 13 p. 1747 - 1750
反应条件
in tetrahydrofuran
T=0 - 20°C;
参考文献
Lantano, Beatriz; Aguirre, Jose M.; Finkieisztein, Liliana; Aiesso, Elba N.; Brunet, Ernesto; Moltrasio, Graciela Y.
Synthetic Communications, 2004 , vol. 34, # 4 p. 625 - 641
参考文献
Larghi, Enrique L.; Kaufman, Teodoro S.
Tetrahedron Letters, 1997 , vol. 38, # 18 p. 3159 - 3162
反应条件
toluene-4-sulfonic acid in dichloromethane
参考文献
Inayama,S. et al.
Journal of Medicinal Chemistry, 1976 , vol. 19, p. 433 - 436
反应条件
sodium hydroxide; acetic acid; zinc in tetrahydrofuran; methanol; water
T=-8 - -2°C;
参考文献
Lobo, Ana M.; Prabhakar, Sundaresan; Rzepa, Henry S.; Skapski, Andrzej C.; Tavares, M. Regina; Widdowson, David A.
Tetrahedron, 1983 , vol. 39, # 22 p. 3833 - 3842
反应条件
1: 95 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 20 h / Ambient temperature
2: 95 percent / H2 / Pd/C
3: 93 percent / polyphosphoric acid / 4 h / 40 °C
4: 3 percent / HBr
5: 100 percent / K2CO3 / dimethylformamide / Heating
6: 42 percent / NH3(liq.), t-C4H9OK, air / Irradiation
7: 96 percent / 30percent Pd/C / 4 h / 250 °C
8: 90 percent / 48percent HBr / acetic acid / 3 h / 100 °C
View Scheme
参考文献
Beugelmans, Rene; Chastanet, Jacqueline; Ginsburg, Helene; Quintero-Cortes, Leticia; Roussi, Georges
Journal of Organic Chemistry, 1985 , vol. 50, # 24 p. 4933 - 4938
反应条件
sodium hydroxide in ethanol
参考文献
Bayomi, Said M.; El-Kashef, Hassan A.; El-Ashmawy, Mahmoud B.; Nasr, Magda N. A.; El-Sherbeny, Magda A.; Badria, Farid A.; Abou-Zeid, Laila A.; Ghaly, Mariam A.; Abdel-Aziz, Naglaa I.
Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1147 - 1162
