3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
1.1: sodium hydride / tetrahydrofuran; dimethyl sulfoxide; mineral oil / 0.17 h / 0 °C / |Inert atmosphere
1.2: 20 h / 0 - 20 °C / |Inert atmosphere
2.1: palladium on activated charcoal / methanol / 0.17 h / 20 °C / |Inert atmosphere
2.2: 4 h / |Inert atmosphere
3.1: polyphosphoric acid / dichloromethane / 4 h / |Inert atmosphere; |Reflux
4.1: pyridine; hydroxylamine hydrochloride / 4 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
De, Subhadip; Mishra, Sourabh; Kakde, Badrinath N.; Dey, Dhananjay; Bisai, Alakesh
Journal of Organic Chemistry, 2013 , vol. 78, # 16 p. 7823 - 7844
反应条件
hydrazine hydrate in ethanol
参考文献
Nenajdenko, Valentine G.; Muzalevskiy, Vasiliy M.; Shastin, Aleksey V.; Balenkova, Elizabeth S.; Haufe, Guenter
Journal of Fluorine Chemistry, 2007 , vol. 128, # 7 p. 818 - 826
反应条件
1: 80 percent / piperidine
2: CuCl / diethyl ether / 3 h / ice-bath
3: aq.KOH / 3 h / Heating
4: 71 percent / aq.H2SO4 / 8 h / Heating
5: 55 percent / polyphosphoric acid (PPA) / 1 h / Heating
View Scheme
参考文献
Selvaraj, S.; Rajendran, A. S.; Arumugam, N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 1047 - 1049
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran
1.2: -78 - 20 °C
2.1: sodium tetrahydroborate / tetrahydrofuran; water
3.1: 4-acetylamino 2,2,6,6-tetramethylpiperidin-N-oxyl; nitric acid; sodium nitrite / water; acetic acid / 12 h / 20 °C / 760.05 Torr
View Scheme
参考文献
Rahimi, Alireza; Azarpira, Ali; Kim, Hoon; Ralph, John; Stahl, Shannon S.
Journal of the American Chemical Society, 2013 , vol. 135, # 17 p. 6415 - 6418
反应条件
trimethyl-(2-hydroxyethyl)ammonium chloride; urea
T=80°C; 12 h; Sealed tube;
参考文献
Hawkins, Ian; Handy, Scott T.
Tetrahedron, 2013 , vol. 69, # 44 p. 9200 - 9204
反应条件
hydrogenchloride; ethanol
参考文献
Freudenberg; Fikentscher; Harder
Justus Liebigs Annalen der Chemie, 1925 , vol. 441, p. 159,166
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere
1.2: 16.25 h / 20 °C
2.1: iodine / dimethyl sulfoxide / 12 h / 190 °C / Reflux
View Scheme
参考文献
Sagrera, Gabriel; Bertucci, Ana; Vazquez, Alvaro; Seoane, Gustavo
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 10 p. 3060 - 3073
反应条件
sodium hydride
1.) toluene, oil, 30 min, 2.) 60 deg C, 18 h; Multistep reaction;
参考文献
Boshoff, Philip R.; Perold, Guido W.
Journal of Chemical Research, Miniprint, 1986 , # 2 p. 735 - 745
反应条件
water; potassium carbonate in 1,4-dioxane
T=95°C; 6 h;
参考文献
Bigot, Yves Le; Delmas, Michel; Gaset, Antoine
Tetrahedron, 1986 , vol. 42, # 1 p. 339 - 350
反应条件
in toluene
T=80°C; 50 h;
参考文献
Bansal, R. K.; Mathur, Suchitra; Jain, Jainendra K.; Sharma, Diwakar
Journal of the Indian Chemical Society, 1988 , vol. 65, p. 134 - 136
