3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
Multi-step reaction with 2 steps 1: sodium methoxide2: 80 percent / H2, NEt3 / <Rh(1,5-cyclooctadiene)Cl>2, (4S,5S)-MOD-DIOP (12) / methanol / 40 h / 30 °C / 760 Torr
参考文献
Morimoto, Toshiaki; Chiba, Mitsuo; Achiwa, Kazuo Tetrahedron, 1993 , vol. 49, # 9 p. 1793 - 1806
反应条件
With 2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane T=0°C; pH=7; 1.25 h; aq. buffer;
参考文献
Dunetz, Joshua R.; Julian, Lisa D.; Newcom, Jason S.; Roush, William R. Journal of the American Chemical Society, 2008 , vol. 130, # 48 p. 16407 - 16416
反应条件
Multi-step reaction with 3 steps 1: 68 percent / acetic anhydride / Heating2: 84 percent / Na2CO3 3: H2 / <Rh(R-PROPHOS)(NBD)>PF6 / tetrahydrofuran / 17 h
参考文献
O'Reilly; Derwin; Lin Synthesis, 1990 , # 7 p. 550 - 556
反应条件
Multi-step reaction with 7 steps 1: KOH / methanol; H2O / 0.25 h / Heating2: H2 / 10 percent Pd/C / ethyl acetate / 0.75 h / 724.01 - 1086.01 Torr3: 89 percent / sodium sand / Ambient temperature4: 98 percent / H2 / 10 percent Pd/C / ethyl acetate / 4 h / 1292.9 Torr5: 1) NaHMDS, 2) (+)-8,8-dichlorocamphorylsuflonyl oxaziridine 7b / 1) THF, -78 deg C, 30 min, 2) 30 min6: 91 percent / NaBH4 / ethanol / 2 h / Ambient temperature7: HCl / methanol / 2 h / Heating
参考文献
Davis; Chen Journal of Organic Chemistry, 1993 , vol. 58, # 7 p. 1751 - 1753
反应条件
Multi-step reaction with 5 steps 1: ammonium acetate / 3 h / Heating2: LiAlH4 / tetrahydrofuran / 4 h / Ambient temperature3: benzene / Heating4: NaBH4 / ethanol / 0.5 h / Ambient temperature5: K2CO3 / Ambient temperature
参考文献
Kubo, Akinori; Saito, Naoki; Kawakami, Nanko; Matsuyama, Yasuo; Miwa, Teruyo Synthesis, 1987 , # 9 p. 824 - 827
反应条件
Multi-step reaction with 4 steps 1: 99 percent / KOH / ethanol / 3 h / 20 °C2: 90 percent / BBr3 / CH2Cl2 / 0.5 h / 0 °C3: 65 percent / dimethyl dioxirane / acetone; CH2Cl2 / 1 h / 0 - 20 °C4: 95 percent / K2CO3 / acetone / 6 h / Heating
参考文献
Chu, Han-Wei; Wu, Huan-Ting; Lee, Yean-Jang Tetrahedron, 2004 , vol. 60, # 11 p. 2647 - 2655
反应条件
Show Experimental Procedure
参考文献
Tanabe Seiyaku Co., Ltd. Patent: US5070103 A1, 1991 ;
反应条件
Multi-step reaction with 2 steps 1: MCPBA / CH2Cl2 / 24 h / Ambient temperature2: 92 percent / NaBH4 / methanol / 0 °C
参考文献
Chiba, Kazuhiro; Sonoyama, Junko; Tada, Masahiro Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 12 p. 1435 - 1443
反应条件
Multi-step reaction with 2 steps 1: sodium / ethanol / 1 h / 85 °C / Inert atmosphere2: VOCl3 / dichloromethane / 1 h / -78 °C / Inert atmosphere
参考文献
National Health Research Institutes Patent: US2011/172261 A1, 2011 ;
反应条件
Multi-step reaction with 2 steps 1: sodium2: amalgamated aluminium; diethyl ether
参考文献
Lewis; Ramage; Robinson Journal of the Chemical Society, 1935 , p. 1412
