3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
hydrogenchloride; sodium hydroxide
参考文献
Eli Lilly and Company
Patent: US3987200 A1, 1976 ;
反应条件
1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate; 2-(3,4-dimethoxyphenyl)-ethylamine in dichloromethane T=20°C; 4 h; 2: (carboxymethyl)trimethylammonium chloride hydrazide in methanol; dichloromethane
参考文献
ACS Combinatorial Science, , vol. 15, # 4 p. 208 - 215
反应条件
1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate; 2-(3,4-dimethoxyphenyl)-ethylamine in dichloromethane T=20°C; 4 h; 2: (carboxymethyl)trimethylammonium chloride hydrazide in methanol; dichloromethane
参考文献
ACS Combinatorial Science, , vol. 15, # 4 p. 208 - 215
反应条件
hydrogen; nickel monoaluminide; palladium in diethyl ether; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US3987200 A1, 1976 ;
反应条件
1: CH2Cl2 / 24 h / 20 °C 2: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 3: 81 percent / Et3N / CH2Cl2 / 1.5 h / 0 °C 4: 91 percent / m-CPBA / CH2Cl2 / 1 h / 0 °C 5: 25 percent / CH3SO3H / CCl4 / 0.33 h / Heating 6: 90 percent / Raney Ni / ethanol / 2 h / Heating 7: POCl3; K2CO3 / acetonitrile / 0.67 h / 60 °C 8: NaBH4 / methanol / 1 h / Heating View Scheme
参考文献
Vinogradova, V. I.; Yunusov, M. S.; Rezhepov, Zh.; Sadritdinov, F. F.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 1 p. 30 - 31
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 1 p. 44 - 45
反应条件
cerium(III) chloride heptahydrate; glycerol T=20°C; 1 h; regioselective reaction;
参考文献
Narsaiah, A. Venkat; Wadavrao, Sachin B.; Reddy, A. Ramesh; Yadav
Synthesis, 2011 , # 3 art. no. Z25910SS, p. 485 - 489
参考文献
Crowther,A.F.; Smith,L.H.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 5 p. 1009 - 1013
反应条件
1: α-phenylbenzeneacetic acid; 4-methyl-benzoic acid With thionyl chloride Combinatorial reaction / High throughput screening (HTS); 2: 2-(4-hydroxyphenyl)ethylamine; 1-adamantaneamine; 2-(4-methylphenyl)-ethylamine; 2-(3,4-dimethoxyphenyl)-ethylamine; phenethylamine; 2-(4-methoxy-phenyl)ethylamine; 3,4,5-trimethoxy-phenylamine; 2-(3-methoxy-phenyl)-ethylamine; 1-amino-2-(2-methoxyphenyl)ethane; (1R*,2S*)-2-methylamino-1-phenyl-1-propanol
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Patent: WO2005/44191 A2, 2005 ;
Location in patent: Figure 12 ;
反应条件
1: bis[N(C2H5)2]-bis{[N-((2,6-iPr)phenyl)]benzamidate}titanium / benzene / 24 h / 65 °C 2: 202 mg / trifluoroacetic acid / benzene / 12 h / Heating View Scheme
参考文献
Santangelo Freel, Rose M.; Ogden, Kevin K.; Strong, Katie L.; Khatri, Alpa; Chepiga, Kathryn M.; Jensen, Henrik S.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5351 - 5381
反应条件
formic acid T=95°C; Pictect-Spengler reaction;
参考文献
Karageorge, George N.; Bertenshaw, Stephen; Iben, Lawrence; Xu, Cen; Sarbin, Nathan; Gentile, Anthony; Dubowchik, Gene M.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5881 - 5884
