3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
acetic acid; trifluoroacetic acid 5 h; Reflux;
参考文献
AUSPEX PHARMACEUTICAL ,INC.; GANT, Thomas, G.; SHAHBAZ, Manoucherhr
Patent: WO2010/44981 A2, 2010 ;
Location in patent: Page/Page column 28 ;
反应条件
1: 14 h; Reflux; 2: With phosphorus pentachloride in dichloromethane T=20°C; 2 h;
参考文献
Imbri, Dennis; Tauber, Johannes; Opatz, Till
Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15080 - 15083
反应条件
1: 100 percent / methanol / 12 h / Ambient temperature 2: 89 percent / POCl3 / toluene View Scheme
参考文献
ENALTEC LABS PVT. LTD.; SIVA KUMAR Venkata Bobba; ESWARA Rao Kodali; GIRISH, Bansilal Patel; SANJAY, Dashrath, Vaidya; ALOK PRAMOD Tripathi
Patent: WO2012/81031 A1, 2012 ;
反应条件
formic acid Pictet-Spengler reaction; 1 h; Heating;
参考文献
Heterocycles, , vol. 55, # 8 p. 1569 - 1580
反应条件
trichlorophosphate T=190 - 200°C; 2.5 h; Yield given;
参考文献
Langhals, Elke; Langhals, Heinz; Ruechardt, Christoph
Chemische Berichte, 1984 , vol. 117, # 4 p. 1436 - 1454
参考文献
Zou, Zhi-Hong; Lan, Xiao-Bu; Qian, Hai; Huang, Wen-Long; Li, Yun-Man
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5934 - 5938
反应条件
iodine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide T=65°C; 3 h;
参考文献
Chiampanichayakul, Supanimit; Pohmakotr, Manat; Reutrakul, Vichai; Jaipetch, Thaworn; Kuhakarn, Chutima
Synthesis, 2008 , # 13 p. 2045 - 2048
反应条件
1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature 4: 51 percent / benzene / 48 h / Heating View Scheme
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524
反应条件
in trifluoroacetic acid 20 h; Heating;
参考文献
Singh
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 10 p. 802 - 805
反应条件
acetic acid; sodium nitrite
参考文献
Schoepf et al.
Justus Liebigs Annalen der Chemie, 1949 , vol. 563, p. 86,89
Full Text Show Details
Buck
Journal of the American Chemical Society, 1931 , vol. 53, p. 2192,2195,2198
