3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature 4: 51 percent / benzene / 48 h / Heating 5: 85 percent / acetonitrile / 48 h / Ambient temperature View Scheme
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524
反应条件
1: aq. K2CO3 / 1.5 h / 20 °C 2: p-toluenesulfonic acid / CH2Cl2 / Heating 3: H2; HCO2H / 10 percent Pd/C / methanol / 30 h / 20 °C / 760 Torr View Scheme
参考文献
Soni, Rina; Cheung, Fung Kei; Clarkson, Guy C.; Martins, Jose E. D.; Graham, Mark A.; Wills, Martin
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3290 - 3294
反应条件
acetic acid in acetonitrile 15 h; Ambient temperature;
参考文献
Singh
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 10 p. 802 - 805
反应条件
1: 99 percent / tetrahydrofuran / 2 h / 25 °C 2: 93 percent / I2; HIO3 / methanol; H2O / 48 h / 85 °C 3: 84 percent / CuI; PPh3; iPr2NH / Pd(PPh3)2Cl2 / 16 h / 25 °C 4: 90 percent / KOH / methanol; H2O / 20 h / 25 °C 5: 98 percent / Cp2TiMe2 / toluene / 16 h / 110 °C View Scheme
参考文献
Kaur, Jaskiran; Ghosh, Narendra Nath; Talwar, Anita; Chandra, Ramesh
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 9 p. 1223 - 1228
反应条件
PPA in dichloromethane T=80°C; 72 h;
参考文献
Venkov, Atanas P.; Ivanov, Ilian I.
Tetrahedron, 1996 , vol. 52, # 37 p. 12299 - 12308
反应条件
trichlorophosphate in toluene T=20 - 120°C; Bischler-Napieralski reaction; 3.5 h;
参考文献
Gan, Haifeng; Lu, Yunyu; Huang, Yue; Ni, Lijun; Xu, Jinyi; Yao, Hequan; Wu, Xiaoming
Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1320 - 1324
反应条件
T=130°C; P=90007.2 - 97507.8 Torr; 24 h;
参考文献
Dunetz, Joshua R.; Ciccolini, Rocco P.; Froeling, Morgan; Paap, Scott M.; Allen, Andrew J.; Holmes, Andrew B.; Tester, Jefferson W.; Danheiser, Rick L.
Chemical Communications, 2005 , # 35 p. 4465 - 4467
反应条件
in chlorobenzene T=115°C;
参考文献
Massiot, Georges; Levy, Jean
Bulletin de la Societe Chimique de France, 1981 , vol. 2, # 11-12 p. 463 - 467
反应条件
1: 96 percent / Et3N, DMAP / CH2Cl2 / Ambient temperature 2: 84 percent / LiAlH4 / tetrahydrofuran / 6 h / Heating 3: 1.) n-BuLi, 2.) n-BuLi View Scheme
参考文献
Lete, Esther; Collado, M. Isabel; Sotomayor, Nuria; Vicente, Teresa; Villa, Maria-Jesus
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1751 - 1758
