3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
1: aq. Na2CO3 / CHCl3 / 0 °C 2: POCl3 / toluene / Heating 3: tetralin / 10percent Pd/C / 220 - 230 °C View Scheme
参考文献
Wu, Jianjun; Talwar, Dinesh; Johnston, Steven; Yan, Ming; Xiao, Jianliang
Angewandte Chemie - International Edition, 2013 , vol. 52, # 27 p. 6983 - 6987
Ross. Khim. Zh., 2013 , vol. 125, # 27 p. 7121 - 7125,5
反应条件
in benzene 4 h; Ambient temperature;
参考文献
Stezhko, T. V.; Granik, V. G.; Kadushkin, A. V.; Glushkov, R. G.; Roshchina, L. F.; et al.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 10 p. 692 - 697
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 10 p. 1198 - 1203
参考文献
Boehringer Ingelheim GmbH
Patent: US4021558 A1, 1977 ;
反应条件
in isopropyl alcohol T=60°C; Michael Addition; 2.5 h; Inert atmosphere; Solvent;
参考文献
Armitage, Mark A.; Smith, Gillian E.; Veal, Kenneth T.
Organic Process Research and Development, 1999 , vol. 3, # 3 p. 189 - 195
反应条件
1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature 4: 51 percent / benzene / 48 h / Heating View Scheme
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524
反应条件
1: 59 percent / 160 °C 2: 64 percent / POCl3 / toluene / 1 h / Heating 3: 90.9 percent / hydrogen / Pd/BaSO4 / methanol / 40 °C / 750.06 Torr View Scheme
参考文献
Glusa; Gruner; Hagen; Lohmann; Foken
Pharmazie, 1990 , vol. 45, # 6 p. 408 - 410
反应条件
1.1: N,O-bis(trimethylsilyl)acetamide / dimethylsulfoxide / 0.5 h / 20 °C 1.2: 70 percent / dimethylsulfoxide / 35 h / 85 °C 2.1: 65 percent / H2 / 10 percent Pd/C / ethanol / 12 h / 20 °C / 2585.74 Torr View Scheme
参考文献
Jian-Xin, Gu; Zu-Yi, Li; Guo-Qiang, Lin
Tetrahedron, 1993 , vol. 49, # 26 p. 5805 - 5816
反应条件
1: silver oxide; ethanol 2: phosphorus (V)-oxide; toluene View Scheme
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524
反应条件
1: 81 percent / 6 h / 140 °C 2: 60 percent / POCl3 / toluene; ethanol / 3.5 h / Heating View Scheme
参考文献
Koelzer, Michael; Weitzel, Kerstin; Goeringer, H. Ulrich; Thines, Eckhard; Opatz, Till
ChemMedChem, 2010 , vol. 5, # 9 p. 1456 - 1464
反应条件
in dichloromethane T=0°C; 1 h;
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
