3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
hydrogenchloride in ethanol Pictet-Spengler reaction;
参考文献
Zhu, Ju; Lu, Jiaguo; Zhou, Youjun; Li, Yaowu; Cheng, Jun; Zheng, Canhui
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5285 - 5289
反应条件
hydrogenchloride in water 8 h; Heating;
参考文献
Stenlake; Waigh; Urwin; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 508 - 514
反应条件
1: 91 percent / aq. K2CO3 / diethyl ether / 1.5 h / 0 °C 2: 83 percent / P4O10 / toluene / 1.17 h / 110 °C 3: 93 percent / H2 / Pd/C / acetic acid; ethanol / 1.33 h / 3075.25 Torr View Scheme
参考文献
Zheng, Pinguan; Lieberman, Brian P.; Choi, Seok Rye; Ploeessl, Karl; Kung, Hank F.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3435 - 3438
反应条件
hydrogenchloride; hydrogen; palladium monocarbide in dichloromethane; water; ethyl acetate; isopropyl alcohol
反应条件
1: POCl3 / 2.5 h / 190 - 200 °C 2: 30 percent / 10 percent Pd/C / decahydronaphthalene / 1.5 h / 190 °C 3: 93 percent / 1 h / Heating View Scheme
参考文献
Langhals, Elke; Langhals, Heinz; Ruechardt, Christoph
Chemische Berichte, 1984 , vol. 117, # 4 p. 1436 - 1454
反应条件
1: calcium oxide; benzene 2: phosphoryl chloride; benzene View Scheme
参考文献
Chang, Mingxin; Li, Wei; Zhang, Xumu
Angewandte Chemie - International Edition, 2011 , vol. 50, # 45 p. 10679 - 10681
参考文献
Gupta; Saxena; Jain; Anand
Archiv der Pharmazie, 1984 , vol. 317, # 12 p. 1010 - 1017
反应条件
1: benzene / Heating 2: NaBH4 / ethanol / 0.5 h / Ambient temperature 3: K2CO3 / Ambient temperature 4: trifluoroacetic acid / 1 h / Ambient temperature View Scheme
参考文献
Kubo, Akinori; Saito, Naoki; Kawakami, Nanko; Matsuyama, Yasuo; Miwa, Teruyo
Synthesis, 1987 , # 9 p. 824 - 827
反应条件
1,3,2-benzodithiazole 1,1,3,3-tetraoxide T=80°C; Pictet-Spengler reaction; 6 h; neat (no solvent);
参考文献
Barbero, Margherita; Bazzi, Stefano; Cadamuro, Silvano; Dughera, Stefano
Tetrahedron Letters, 2010 , vol. 51, # 48 p. 6356 - 6359
反应条件
1: POCl3 / toluene / 3.5 h / 20 - 120 °C 2: NaBH4 / methanol / 2.5 h / 20 °C View Scheme
参考文献
Huang, Wei-Jan; Singh, Om V.; Chen, Chung-Hsiung; Lee, Shoei-Sheng
Helvetica Chimica Acta, 2004 , vol. 87, # 1 p. 167 - 174
