3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
potassium carbonate in dichloromethane 2 h; Heating;
参考文献
Ma, Chen; Cho, Su-Dong; Falck; Shin, Dong-Soo
Synthetic Communications, 2004 , vol. 34, # 8 p. 1399 - 1405
反应条件
1: 2 h / Heating 2: 4.74 g / POCl3 / toluene / Heating 3: 83 percent / NaBH4 / methanol / 1 h / 20 °C View Scheme
参考文献
Sobarzo-Sanchez, Eduardo; Castedo, Luis; De La Fuente, Julio R.
Synthetic Communications, 2007 , vol. 37, # 8 p. 1331 - 1338
反应条件
1: 93.6 percent / H2SO4 / 2 h / Heating 2: 77.3 percent / toluene / 0 °C View Scheme
参考文献
Lebedev; Lebedeva; Sheludyakov; Ovcharuk; Kovaleva; Ustinova
Russian Journal of General Chemistry, 2006 , vol. 76, # 3 p. 469 - 477
反应条件
in toluene T=100°C; Cooling with ice;
参考文献
Wang, Liutang; Zhang, Bin; Ji, Jianxin; Li, Bogang; Yan, Jufang; Zhang, Weiyu; Wu, Yong; Wang, Xuechao; Hou, Hui
Synthetic Communications, 2010 , vol. 40, # 1 p. 52 - 57
反应条件
1: bromine / acetic acid 2: copper diacetate; palladium diacetate; potassium carbonate / toluene / 24 h / Inert atmosphere; Reflux View Scheme
参考文献
Harada, Rika; Nishida, Naoto; Uchiito, Shiho; Onozaki, Yu; Kurono, Nobuhito; Senboku, Hisanori; Masao, Tokuda; Ohkuma, Takeshi; Orito, Kazuhiko
European Journal of Organic Chemistry, 2012 , # 2 p. 366 - 379
反应条件
1.1: dichloromethane / 1 h / 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 20 - 80 °C 3.1: hydrogenchloride / ethanol / 2 h / 20 °C 4.1: triethylamine / dichloromethane / 0 - 20 °C 5.1: potassium carbonate / water; methanol / 1 h / 20 °C 6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2.5 h / -78 °C 6.2: 3 h / 20 °C 7.1: dichloromethane / 20 °C 7.2: 3 h / 20 °C 8.1: Raney nickel / ethanol; water / 1 h / Reflux View Scheme
参考文献
LES LABORATOIRES SERVIER; LE FLOHIC, Alexandre; GRANDJEAN, Mathieu
Patent: US2013/261298 A1, 2013 ;
反应条件
DCN; oxygen in methanol Irradiationor with 9,10-dihydroanthracene, MeCN;
参考文献
Pandey; Sridhar; Bhalerao
Tetrahedron Letters, 1990 , vol. 31, # 37 p. 5373 - 5376
反应条件
sodium hydroxide; thionyl chloride in methanol; dichloromethane; chloroform
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP624584 A1, 1994 ;
反应条件
triethylamine in chloroform
参考文献
Yason S.R.L.; SIR International S.A.
Patent: US4956389 A1, 1990 ;
反应条件
hydrogenchloride; water T=100°C; 144 h;
参考文献
Velcicky, Juraj; Soicke, Arne; Steiner, Roland; Schmalz, Hans-Guenther
Journal of the American Chemical Society, 2011 , vol. 133, # 18 p. 6948 - 6951
