3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Awuah, Emelia; Capretta, Alfredo
Journal of Organic Chemistry, 2010 , vol. 75, # 16 p. 5627 - 5634
反应条件
tetra-(n-butyl)ammonium iodide 1) electrolysis, DMF, Hg-cathode, 2 h; Yield given. Multistep reaction;
参考文献
Hess Komenda; Hollwarth; Dunkel
Pharmazie, 1992 , vol. 47, # 11 p. 848 - 851
反应条件
T=150°C; 0.5 h; Microwave irradiation;
参考文献
Wu, Jianjun; Talwar, Dinesh; Johnston, Steven; Yan, Ming; Xiao, Jianliang
Angewandte Chemie - International Edition, 2013 , vol. 52, # 27 p. 6983 - 6987
Ross. Khim. Zh., 2013 , vol. 125, # 27 p. 7121 - 7125,5
反应条件
sodium hydroxide in chloroform 0.5 h;
参考文献
Wert, Kathleen L.; Chackalamannil, Samuel; Miller, Eric; Dalton, David R.; Zacharias, David E.; Glusker, Jenny P.
Journal of Organic Chemistry, 1982 , vol. 47, # 26 p. 5141 - 5150
反应条件
sodium hydroxide; thionyl chloride in methanol; dichloromethane; chloroform
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP624584 A1, 1994 ;
参考文献
Onda
Yakugaku Zasshi, 1954 , vol. 74, p. 925
Chem.Abstr., 1955 , p. 10962
反应条件
1: 46 percent / K2CO3 / ethanol / 24 h / Heating 2: 74 percent / SOCl2 / CHCl3 / 0.75 h / Heating 3: NaI, K2CO3 / dimethylformamide / 13 h / 60 °C View Scheme
参考文献
Fujimura, Ken-Ichi; Matsumoto, Junzo; Niwa, Masashi; Kobayashi, Tadayuki; Kawashima, Yoichi; In, Yasuko; Ishida, Toshimasa
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1675 - 1683
反应条件
1: 96 percent / Et3N / CH2Cl2 / 6 h / 20 °C 2: 42 percent / Et3N / Pd(OAc)2 / acetonitrile / 6 h / 20 °C 3: 74 percent / Sn(OTf)2 / CH2Cl2 / 0 °C 4: 83 percent / PhSK / acetonitrile / 32 h / 20 °C View Scheme
参考文献
Kinderman, Sape S.; Wekking, Monique M. T.; Van Maarseveen, Jan H.; Schoemaker, Hans E.; Hiemstra, Henk; Rutjes, Floris P. J. T.
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5519 - 5527
反应条件
1: 100 percent / Et3N / CH2Cl2 2: 58 percent / phosphoryl chloride / 18 h 3: 96 percent / butan-2-one / 9 h / Heating View Scheme
参考文献
Pitts; Harrison; Moody
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 9 p. 955 - 977
参考文献
Pharmaceutical Chemistry Journal, , vol. 23, # 10 p. 849 - 852
Khimiko-Farmatsevticheskii Zhurnal, , vol. 23, # 10 p. 1235 - 1237
