3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
1.) ref., 16 h: 2.) ref., 45 min.; Yield given. Multistep reaction;
参考文献
Ordaz, Candido; Ferrigni, Nelson R.; Mclaughlin, Jerry L.
Phytochemistry (Elsevier), 1983 , vol. 22, # 9 p. 2101 - 2102
反应条件
1.1: anhydrous xylene / 4 h / |Reflux; |Dean-Stark 2.1: trichlorophosphate / acetonitrile / 4 h / 100 °C / |Inert atmosphere 3.1: sodium tetrahydroborate / 1,4-dioxane; ethanol / 3.5 h / 100 °C 3.2: 1.25 h / 80 °C View Scheme
参考文献
Vilhanova, Beata; Matousek, Vaclav; Vaclavik, Jiri; Syslova, Kamila; Prech, Jan; Pechacek, Jan; Sot, Petr; Januscak, Jakub; Toman, Jaromir; Zapal, Jakub; Kuzma, Marek; Kacer, Petr
Tetrahedron Asymmetry, 2013 , vol. 24, # 1 p. 50 - 55
反应条件
1: 63 percent / Na2CO3 / light petroleum / 15 h 2: 6.5 percent / benzene / 10 h / Ambient temperature; Irradiation View Scheme
参考文献
Ishibashi, Hiroyuki; Sato, Kazumi; Ikeda, Masazumi; Maeda, Hiroshi; Akai, Shuji; Tamura, Yasumitsu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 605 - 610
反应条件
in N,N-dimethyl-formamide T=100 - 110°C; 3 h;
参考文献
Povalyaeva, O. S.; Kurkovskaya, L. N.; Vigdorchik, M. M.; Suvorov, N. N.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 6 p. 1171 - 1179
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 6 p. 1294 - 1304
反应条件
1: 2 h / |Cooling with ice; |Reflux; |Inert atmosphere 2: phosphorus pentachloride / dichloromethane / 1.5 h / 35 - 40 °C / |Inert atmosphere 3: hydrogenchloride / 20 °C / |Inert atmosphere View Scheme
参考文献
Orejarena Pacheco, Julio Cesar; Lahm, Guenther; Opatz, Till
Journal of Organic Chemistry, 2013 , vol. 78, # 10 p. 4985 - 4992
反应条件
1: 79 percent / K2CO3 / acetonitrile
2: 51 percent / H2SO4 / trifluoroacetic acid; CH2Cl2
3: 85 percent / HCOOH
View Scheme
参考文献
Coote, Steven J.; Davies, Stephen G.; Middlemiss, David; Naylor, Alan
Tetrahedron: Asymmetry, 1990 , vol. 1, # 1 p. 33 - 56
反应条件
in acetic acid
4 h; Heating;
参考文献
Manteca, Izaskun; Etxarri, Begona; Ardeo, Ainhoa; Arrasate, Sonia; Osante, Inaki; Sotomayor, Nuria; Lete, Esther
Tetrahedron, 1998 , vol. 54, # 40 p. 12361 - 12378
反应条件
Condensation; 0.25 h; Heatingmicrowave irradiation;
参考文献
Seijas, Julio A.; Vazquez-Tato, M. Pilar; Martinez, M. Montserrat; Nunez-Corredoira, Gonzalo
Journal of Chemical Research - Part S, 1999 , # 7 p. 420 - 421
反应条件
1: 99 percent / CH2Cl2 / 1 h / 0 °C
2: 82 percent / NaH / tetrahydrofuran / 4 h / Ambient temperature
3: Et3N / tetrahydrofuran / 48 h / 80 °C
View Scheme
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
反应条件
1: 99 percent / CH2Cl2 / 1 h / 0 °C
2: 82 percent / NaH / tetrahydrofuran / 4 h / Ambient temperature
3: Et3N / tetrahydrofuran / 48 h / 80 °C
View Scheme
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
