3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
1: 92 percent / toluene / 2.5 h / Heating
2: 60 percent / POCl3 / ethanol; tetrachloroethene / 1.5 h / 120 - 130 °C
3: 90 percent / 4N HCl, hydrogen / PtO2 / ethanol / 4 h / 2625.2 Torr
4: 83 percent / 10percent NaOH / CH2Cl2
5: 98 percent / HCOOH / 10 h / 85 °C
View Scheme
参考文献
Locher, Cornelia; Peerzada, Naseem
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 2 p. 179 - 184
反应条件
1: With sodium sulfate in methanol
T=25°C; Mannich reaction; 10 h;
2: With aluminium trichloride in dichloromethane
10 h; Heating;
3: With sodium tetrahydroborate in tetrahydrofuran
T=25°C;
参考文献
Katritzky, Alan R; He, Hai-Ying; Jiang, Rong; Long, Qiuhe
Tetrahedron Asymmetry, 2001 , vol. 12, # 17 p. 2427 - 2434
反应条件
formic acid
Pictet-Spengler reaction; 1 h; Heating;
参考文献
Ivanov, Iliyan; Venkov, Atanas
Heterocycles, 2001 , vol. 55, # 8 p. 1569 - 1580
反应条件
1: 80 percent / 4 h
2: 94 percent / POCl3 / toluene / 2 h / Heating
3: 81 percent / NaBH4 / ethanol; H2O / 2 h / Ambient temperature
View Scheme
参考文献
Crestey, Francois; Jensen, Anders A.; Borch, Morten; Andreasen, Jesper Tobias; Andersen, Jacob; Balle, Thomas; Kristensen, Jesper Langgaard
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9673 - 9682
反应条件
1: benzene
2: phosphoryl chloride; phosphorus (V)-oxide
3: palladium/charcoal / 200 - 240 °C / Unter Stickstoff
4: phosphoryl chloride
View Scheme
参考文献
Anderson et al.
Journal of the American Pharmaceutical Association (1912-1977), 1952 , vol. 41, p. 643,648
反应条件
1: 43.6 percent / methanol / 20 h / Ambient temperature
2: 77.2 percent / hydrogen / 10percent Pd-C / methanol; H2O / 8 h / Ambient temperature
View Scheme
参考文献
Tominaga; Tone; Nakagawa; Takada; Hoshino; Watanabe
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 8 p. 2166 - 2181
反应条件
Multistep reaction.;
参考文献
Chern, Meei-Shiou; Li, Wen-Ren
Tetrahedron Letters, 2004 , vol. 45, # 45 p. 8323 - 8326
反应条件
1: 96 percent / Et3N, DMAP / CH2Cl2 / Ambient temperature
2: 88 percent / Br2 / acetic acid / 6 h / Ambient temperature
View Scheme
参考文献
Lete, Esther; Collado, M. Isabel; Sotomayor, Nuria; Vicente, Teresa; Villa, Maria-Jesus
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1751 - 1758
反应条件
1: 2-(3,4-dimethoxyphenyl)-ethylamine; [3-amino-2,4-dihydroxyphenyl]phenylmethanone With lithium perchlorate in methanol
T=20°C; Electrochemical reaction;
2: (2,4-dinitro-phenyl)-hydrazine With sulfuric acid; lithium perchlorate in methanol; ethanol
1 h;
参考文献
Largeron, Martine; Neudorffer, Anne; Fleury, Maurice-Bernard
Angewandte Chemie - International Edition, 2003 , vol. 42, # 9 p. 1026 - 1029
反应条件
1: bromine / acetic acid
View Scheme
参考文献
Harada, Rika; Nishida, Naoto; Uchiito, Shiho; Onozaki, Yu; Kurono, Nobuhito; Senboku, Hisanori; Masao, Tokuda; Ohkuma, Takeshi; Orito, Kazuhiko
European Journal of Organic Chemistry, 2012 , # 2 p. 366 - 379
